Effects of inducible nitric oxide synthase inhibition or norepinephrine on the neurovascular coupling in an endotoxic rat shock model

Table 1 Group averaged data for glucose, lactate, pH, pCO2 and hemoglobin for all groups

	Glucose (mg/dL)		Lactate (mmol/L)		pH		pCO₂ (mmHg)		Hemoglobin (mg/l)
	Base	End	Base	End	Base	End	Base	End	Base	End
Control	78 ± 12	82 ± 8	-	0.7 ± 0.7	7.57 ± 0.06	7.53 ± 0.05	32.6 ± 4.5	33.5 ± 2.2	137 ± 7	135 ± 6
1 mg/kg	89 ± 18	55 ± 9***	-	2.5 ± 0.8***	7.53 ± 0.05	7.48 ± 0.04*	34.5 ± 5.1	32.8 ± 2.2	137 ± 6	124 ± 15*
5 mg/kg	74 ± 19	46 ± 15***	-	2.4 ± 0.7***	7.51 ± 0.05	7.46 ± 0.04***	35.5 ± 4.1	32.3 ± 1.7	133 ± 9	122 ± 15**
1 mg/kg. + NE	85 ± 15	68 ± 14*	-	1.4 ± 0.4***	7.52 ± 0.05	7.48 ± 0.05*	35.4 ± 4.0	34.3 ± 3.1	139 ± 10	119 ± 19**
5 mg/kg + NE	76 ± 14	70 ± 23	-	1.5 ± 0.6***	7.52 ± 0.03	7.46 ± 0.05**	34.8 ± 3.2	32.8 ± 2.5	145 ± 12	122 ± 17**
1 mg/kg + 1400W	78 ± 14	51 ± 7***	-	2.5 ± 0.6***	7.53 ± 0.06	7.46 ± 0.09**	36.4 ± 4.8	35.2 ± 2.6	142 ± 12	121 ± 18**
5 mg/kg + 1400W	73 ± 15	46 ± 8***	-	2.4 ± 0.4***	7.52 ± 0.03	7.46 ± 0.04***	34.8 ± 3.4	34.3 ± 1.4	139 ± 9	120 ± 15**

Data are given as mean ± standard deviation (SD) together with statistical results. Significance is given as: * P < 0.05; ** P < 0.01; *** P < 0.001 compared with baseline. 1400W = N-(3-(aminomethyl)benzyl)acetamidine; NE = norepinephrine; pCO₂ = partial pressure of carbon dioxide.

ISSN: 1364-8535