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Table 4 Multivariate logistic regression analysis for admissions to critical care units with haematological malignancya

From: Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database

 

Number of admissions

Number of deaths

Percentage of deaths

Adjusted

    

Odds ratio (95% CI)

P value

Age

    

< 0.001

   <45 years

1,512

831

55.0

1.14 (1.09 to 1.20)

 

   45 to 54 years

1,053

622

59.1

Per 10-year increase

 

   55 to 64 years

1,716

1,006

58.6

  

   65 to 74 years

1,852

1,171

63.2

  

   75+ years

1,028

609

59.2

  

Sex

    

0.742

   Female

2,818

1,709

60.7

1.02 (0.89 to 1.18)

 

   Male

4,343

2,530

58.3

Reference

 

Diagnostic categoryb

    

< 0.001

   Bone marrow transplant

143

93

65.0

1.88 (1.00 to 3.53)

 

   ALL

254

141

55.5

Reference

 

   AML

591

398

67.3

1.37 (0.86 to 2.20)

 

   CLML

290

165

56.9

1.02 (0.58 to 1.80)

 

   Hodgkin's lymphoma

200

142

71.0

2.38 (1.30 to 4.36)

 

   Non-Hodgkin's lymphoma

944

625

66.2

1.46 (0.92 to 2.31)

 

   Myeloma

378

227

60.1

0.79 (0.47 to 1.35)

 

Highest central temperature

    

0.100

   <36.0°C

127

110

86.6

2.26 (0.97 to 5.29)

 

   36.0 to 38.4°C

3,850

2,205

57.3

Reference

 

   38.5 to 40.9°C

2,900

1,714

59.1

0.94 (0.81 to 1.09)

 

   41.0+°C

121

80

66.1

0.70 (0.41 to 1.20)

 

Lowest systolic blood pressure

    

< 0.001

   <50 mmHg

281

265

94.3

3.66 (1.93 to 6.96)

 

   50 to 59 mmHg

303

251

82.8

1.66 (1.09 to 2.54)

 

   60 to 69 mmHg

601

472

78.5

1.55 (1.15 to 2.08)

 

   70 to 79 mmHg

1,005

667

66.4

1.10 (0.88 to 1.37)

 

   80 to 99 mmHg

2,598

1,493

57.5

1.14 (0.97 to 1.34)

 

   100+ mmHg

2,270

1,018

44.9

Reference

 

Highest heart rate

    

< 0.001

   <110 beats/min

1,895

788

41.6

Reference

 

   110 to 119 beats/min

1,031

553

53.6

1.32 (1.06 to 1.64)

 

   120 to 139 beats/min

2,119

1,326

62.6

1.57 (1.30 to 1.90)

 

   140+ beats/min

2,019

1,503

74.4

2.07 (1.67 to 2.55)

 

Highest respiratory rate, ventilated or nonventilated

    

< 0.001

   <6 breaths/min

217

141

65.0

1.03 (0.69 to 1.53)

 

   6 to 11 breaths/min

1,840

893

48.5

Reference

 

   12 to 13 breaths/min

1,623

1,039

64.0

1.36 (1.12 to 1.65)

 

   14 to 24 breaths/min

2,899

1,743

60.1

1.57 (1.31 to 1.87)

 

   25+ breaths/min

468

344

73.5

2.81 (2.00 to 3.95)

 

PaO2:FiO2

    

< 0.001

   Ventilated

     

<100 mmHg

580

386

66.6

2.78 (2.11 to 3.66)

 

100 to 199 mmHg

888

446

50.2

1.34 (1.07 to 1.69)

 

200+ mmHg

1,162

441

38.0

Reference

 

   Nonventilated

     

<100 mmHg

1,220

1,033

84.7

2.71 (1.45 to 5.06)

 

100 to 199 mmHg

1,374

951

69.2

1.33 (0.72 to 2.45)

 

200+ mmHg

1,108

621

56.1

1.06 (0.58 to 1.95)

 

Lowest arterial pH

    

< 0.001

   <7.15

1,248

1,125

90.1

2.25 (1.71 to 2.96)

 

   7.15 to 7.24

1,129

817

72.4

1.37 (1.11 to 1.70)

 

   7.25 to 7.32

1,457

797

54.7

1.09 (0.91 to 1.30)

 

   7.33 to 7.49

2,453

1,094

44.6

Reference

 

   7.50+

93

61

65.6

2.20 (1.24 to 3.92)

 

Serum sodium

    

<0.001

   <130 mmol/l

285

208

73.0

2.47 (1.70 to 3.60)

 

   130 to 149 mmol/l

6,125

3,486

56.9

Reference

 

   150 to 154 mmol/l

248

196

79.0

1.85 (1.25 to 2.73)

 

   155 to 159 mmol/l

72

63

87.5

3.28 (1.45 to 7.40)

 

   160+ mmol/l

36

28

77.8

1.34 (0.52 to 3.46)

 
  1. aAnalysis of the effect of age, gender, diagnostic category, temperature, systolic blood pressure, heart rate, respiratory rate, PaO2:FiO2, arterial pH and serum sodium on outcome. ALL: acute lymphoblastic leukaemia; AML: acute myeloblastic leukaemia; CI: confidence interval; CLML: chronic lymphocytic or myeloblastic leukaemia. bOnly admissions with a haematological diagnosis as the primary, secondary or ultimate reason for admission were included in this analysis.