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Table 2 Case mix for admissions with haematological malignancy by diagnostic category

From: Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database

 

AML (n = 622)

ALL (n = 272)

CMLL (n = 310)

 

Age, mean (SD)

49.8 (16.8)

33.5 (20.1)

61.7 (16.1)

 

Male, n (%)

331 (53.2)

143 (52.6)

205 (66.1)

 

APACHE II Acute Physiology Score, mean (SD)

20.1 (6.9)

18.6 (6.9)

17.2 (6.9)

 

APACHE II score, mean (SD)

26.3 (7.6)

23.8 (7.2)

24.9 (7.6)

 

ICNARC physiology score, mean (SD)

26.5 (11.1)

24.1 (11.2)

23.7 (11.4)

 

Number of organ system failures, mean (SD)

1.9 (1.2)

1.7 (1.1)

1.5 (1.1)

 

Mechanically ventilated at any time during first 24 hours in the ICU, n (%)

329 (53.1)

129 (47.6)

165 (53.4)

 

Severe sepsis, n (%)

284 (45.7)

121 (44.5)

137 (44.2)

 

Physiology

    

   Lowest platelet count (× 109/l), median (IQR)

26 (13 to 51)

34 (19 to 62)

61 (34 to 121)

 

   Lowest white blood cell count (× 109/l), median (IQR)

2.3 (0.2 to 16.1)

1.9 (0.2 to 6.8)

10.3 (3.1 to 34.6)

 

Mortality, n (%)

    

   Unit

341 (54.8)

116 (42.7)

126 (40.7)

 

   Acute hospitala

398 (67.3)

141 (55.5)

165 (56.9)

 

Unit length of stay (days), median (IQR)

    

   Unit survivor

2.8 (1.0 to 5.6)

2.2 (1.0 to 4.9)

2.2 (1.0 to 6.1)

 

   Unit nonsurvivor

1.5 (0.6 to 4.4)

3.4 (1.0 to 10.2)

1.5 (0.4 to 6.3)

 

   All

1.9 (0.8 to 5.3)

2.6 (1.0 to 6.7)

1.9 (0.8 to 6.1)

 

Acute hospital length of stay (days)a, median (IQR)

    

   Hospital survivor

38 (27 to 62)

39 (21 to 61)

19 (11 to 41)

 

   Hospital nonsurvivor

15 (3 to 27)

23 (8 to 45)

9 (3 to 24)

 

   All

22 (8 to 39)

29 (13 to 51)

15 (7 to 33)

 

Readmission within the same acute hospital stay, n (%)

28 (4.5)

14 (5.2)

18 (5.8)

 

Acute hospital mortality by number of organ system failures, n (%)

    

   0 organ failures

24 (47.1)

10 (27.8)

16 (29.6)

 

   1 organ failure

99 (54.4)

39 (48.2)

51 (45.5)

 

   2 organ failures

114 (65.9)

49 (60.5)

44 (67.7)

 

   3 organ failures

105 (85.4)

31 (79.5)

38 (90.5)

 

   4 organ failures

47 (88.7)

9 (64.3)

15 (93.8)

 

   5 organ failures

9 (100.0)

3 (100.0)

1 (100.0)

 
 

Hodgkin's lymphoma (n = 216)

Non-Hodgkin's lymphoma (n = 1,007)

Bone marrow transplant (n = 156)

Myeloma (n = 397)

Age, mean (SD)

50.7 (17.9)

56.3 (15.8)

40.8 (14.7)

63.0 (11.2)

Male, n (%)

123 (56.9)

611 (60.7)

83 (53.2)

244 (61.5)

APACHE II Acute Physiology Score, mean (SD)

16.7 (7.0)

17.2 (7.4)

18.5 (8.6)

17.1 (7.5)

APACHE II score, mean (SD)

23.2 (7.5)

24.1 (8.0)

23.4 (9.5)

24.3 (7.9)

ICNARC physiology score, mean (SD)

23.2 (11.0)

24.0 (10.9)

24.0 (12.4)

24.2 (10.8)

Number of organ system failures, mean (SD)

1.5 (1.2)

1.5 (1.2)

1.7 (1.3)

1.7 (1.3)

Mechanically ventilated at any time during first 24 hours in the ICU, n (%)

115 (53.5)

528 (52.7)

69 (45.1)

209 (52.8)

Severe sepsis, n (%)

101 (46.8)

414 (41.1)

68 (43.6)

146 (36.8)

Physiology

    

   Lowest platelet count (× 109/l), median (IQR)

75 (29 to 188)

82 (33 to 184)

37 (19 to 62)

95 (47 to 161)

   Lowest white blood cell count (× 109/l), median (IQR)

6.1 (2.1 to 10.5)

6.3 (1.8 to 13.6)

3.7 (0.6 to 8.2)

4.7 (1.9 to 8.8)

Mortality, n (%)

    

   Unit

119 (55.1)

492 (48.9)

74 (47.4)

151 (38.0)

   Acute hospitala

142 (71.0)

625 (66.2)

93 (65.0)

227 (60.1)

Unit length of stay (days), median (IQR)

    

   Unit survivor

2.7 (1.2 to 5.4)

2.9 (1.3 to 6.7)

2.6 (1.1 to 8.3)

2.9 (1.2 to 8.1)

   Unit nonsurvivor

4.5 (1.2 to 8.7)

2.7 (0.9 to 6.4)

3.9 (1.1 to 7.7)

2.8 (0.7 to 7.4)

   All

3.4 (1.2 to 7.2)

2.7 (1.1 to 6.4)

3.0 (1.1 to 7.9)

2.9 (1.1 to 7.7)

Acute hospital length of stay (days)a, median (IQR)

    

   Hospital survivor

24 (12 to 44)

29 (15 to 53)

32 (17 to 63)

34 (18 to 55)

   Hospital nonsurvivor

15 (6 to 26)

15 (6 to 30)

28 (13 to 46)

14 (5 to 25)

   All

17 (8 to 35)

19 (9 to 35)

29 (15 to 54)

20 (9 to 38)

Readmission within the same acute hospital stay, n (%)

16 (7.4)

59 (5.9)

11 (7.1)

10 (2.5)

Acute hospital mortality by number of organ system failures, n (%)

    

   0 organ failures

26 (54.2)

90 (43.7)

6 (25.0)

24 (32.4)

   1 organ failure

43 (71.7)

182 (60.3)

27 (62.8)

54 (49.1)

   2 organ failures

38 (70.4)

197 (75.2)

28 (71.8)

70 (68.0)

   3 organ failures

24 (88.9)

102 (87.9)

13 (72.2)

41 (77.4)

   4 organ failures

10 (100.0)

41 (93.2)

17 (100.0)

27 (100.0)

   5 organ failures

1 (100.0)

13 (92.9)

2 (100.0)

11 (100.0)

  1. Only admissions with a haematological diagnosis as the primary, secondary or ultimate reason for admission are included. The numbers with each diagnosis are greater than in the logistic regression model because admissions missing hospital outcome and readmissions are excluded from the regression analysis. AML: acute myelogenous leukaemia; ALL: acute lymphocytic leukaemia; APACHE: Acute Physiology and Chronic Health Evaluation; APS: Acute Physiology Score; CI: confidence interval; CMLL: chronic myelogenous or chronic lymphocytic leukaemia; ICNARC: Intensive Care National Audit & Research Centre; ICU: intensive care unit; IQR: interquartile range; SD: standard deviation. aExcluding readmissions within the same acute hospital stay.