Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients

Table 3 Global hemodynamic variables and peripheral circulation parameters stratified by StO₂ level before and after resuscitation

	Admission			After 8 hours of resuscitation
	Low StO₂ (n = 10)	Normal StO₂ (n = 12)	P -value	Low StO₂ (n = 10)	Normal StO₂ (n = 12)	P -value
Heart rate (beats/minute)	94 (79 to 122)	91 (82 to 106)	0.90	95 (79 to 113)	98 (74 to 122)	0.90
Mean arterial blood pressure (mmHg)	77 (64 to 94)	79 (72 to 85)	0.87	67 (60 to 75)	72 (68 to 85)	0.14
Central venous pressure (mmHg)	15 (11 to 18)	12 (9 to 14)	0.20	19 (6 to 20)	15 (7 to 15)	0.34
Central venous oxygen saturation (%)	75 (63 to 79)	73 (68 to 84)	0.38	77 (68 to 85)	70 (65 to 80)	0.46
Peripheral flow index (%)	0.2 (0.2 to 0.7)	1.8 (0.8 to 3.7)	0.001	0.9 (0.4 to 1.1)	2.1 (1.2 to 3.0)	0.004
Clinical abnormalities of peripheral perfusion	11 (92%)	3 (30%)	0.006*	9 (90%)	1 (8%)	0.001*
R_incStO₂ (%/second)	1.8 (1.4 to 2.0)	4.0 (2.6 to 4.7)	0.001	1.7 (1.2 to 2.5)	4.4 (2.9 to 4.7)	0.003

Global hemodynamic variables and peripheral circulation parameters in patients with low tissue oxygen saturation (StO₂; <70%) and normal StO₂ (>70%) at admission and after 8 hours of resuscitation. Data expressed as median (25th to 75th percentile) or as n (%). R_incStO₂, rate of StO₂ increase after the vascular occlusion test. *Significant, Fisher's exact test.

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