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Table 5 Surrogate variables of organ function and injury

From: Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study

 

Baseline

12 hours

24 hours

36 hours

48 hours

Creatinine

(mg/dL)

     

TP

2.5 ± 1

2.6 ± 1.2

2.8 ± 1.4

2.8 ± 1.3

2.8 ± 1.4

AVP

2.2 ± 1

2.4 ± 1.1

2.4 ± 1.2

2.5 ± 1.4

2.4 ± 1.2

NE

2.2 ± 1.6

2.6 ± 1.7

2.7 ± 1.7*

2.9 ± 1.8*

3.3 ± 2*

Creatinine, rel.

(%)

     

TP

--

4 ± 16

11 ± 23

13 ± 27

14 ± 35§

AVP

--

11 ± 17

12 ± 26

15 ± 31

10 ± 21§

NE

--

19 ± 23

23 ± 37

34 ± 48

54 ± 77†‡

Bilirubin, tot.

(mg/dL)

     

TP

1.2 ± 0.7

1 ± 0.5

1 ± 0.5

0.9 ± 0.3‡§

0.9 ± 0.3‡§

AVP

1.6 ± 1.3

1.6 ± 1.2

1.8 ± 1.6

2.0 ± 2.0†

2.3 ± 2.8†

NE

1.6 ± 0.9

1.9 ± 0.8

2.0 ± 1.2

2.3 ± 1.7*†

2.8 ± 2.5*†

Bilirubin, dir.

(mg/dL)

     

TP

0.5 ± 0.3

0.5 ± 0.4

0.5 ± 0.3

0.4 ± 0.2§

0.3 ± 0.1‡§

AVP

0.8 ± 0.9

1 ± 1.2

1.1 ± 1.4

1.1 ± 1.5

1.4 ± 1.9*†

NE

0.8 ± 0.5

1.2 ± 0.8

1.2 ± 0.9

1.6 ± 1.7*†

1.9 ± 2.1*†

ASAT

(U/L)

     

TP

52 ± 26

52 ± 33

54 ± 35

53 ± 42

48 ± 34

AVP

63 ± 49

85 ± 57

79 ± 66

119 ± 163

91 ± 95

NE

72 ± 68

89 ± 115

95 ± 132

103 ± 146

90 ± 122

ALAT

(U/L)

     

TP

30 ± 14

34 ± 15

33 ± 14

35 ± 18

30 ± 13

AVP

45 ± 31

58 ± 42

63 ± 53

69 ± 67

81 ± 85

NE

43 ± 45

62 ± 80

68 ± 103

73 ± 114

63 ± 97

Amylase

(U/L)

     

TP

168 ± 97

148 ± 90

133 ± 79

127 ± 79

144 ± 124

AVP

165 ± 111

152 ± 100

143 ± 79

147 ± 110

123 ± 70

NE

203 ± 191

199 ± 182

217 ± 221

206 ± 212

172 ± 152

Lipase

(U/L)

     

TP

138 ± 145

125 ± 92

97 ± 64

144 ± 126

116 ± 91

AVP

133 ± 90

124 ± 68

127 ± 64

136 ± 72

134 ± 65

NE

134 ± 160

198 ± 282

120 ± 96

158 ± 162

115 ± 65

Troponine I

(ng/mL)

     

TP

0.31 ± 0.3

0.31 ± 0.51

0.22 ± 0.41

0.19 ± 0.35

0.18 ± 0.3

AVP

0.56 ± 1

0.84 ± 1.5

1.23 ± 2.4

1.37 ± 2.5

1.17 ± 2

NE

0.58 ± 0.9

0.66 ± 0.8

0.72 ± 0.75

0.69 ± 0.86

0.63 ± 1

Platelet count

(103 cells/μL)

     

TP

119 ± 68

103 ± 59

93 ± 59*

78 ± 48*

73 ± 41*

AVP

110 ± 56

102 ± 63

95 ± 53

95 ± 55

93 ± 50

NE

114 ± 64

102 ± 52

99 ± 58

94 ± 60

94 ± 69

INR

     

TP

1.4 ± 0.2

1.4 ± 0.2

1.4 ± 0.2

1.4 ± 0.2

1.4 ± 0.2

AVP

1.5 ± 0.5

1.5 ± 0.3

1.5 ± 0.5

1.5 ± 0.4

1.5 ± 0.5

NE

1.5 ± 0.3

1.5 ± 0.3

1.4 ± 0.4

1.3 ± 0.2

1.4 ± 0.3

APTTr

     

TP

1.7 ± 0.6

1.6 ± 0.5

1.6 ± 0.4

1.8 ± 0.6

1.7 ± 0.7

AVP

1.5 ± 0.5

1.5 ± 0.6

1.6 ± 0.7

1.6 ± 0.7

1.7 ± 0.7

NE

1.5 ± 0.2

1.4 ± 0.2

1.4 ± 0.2

1.4 ± 0.2

1.6 ± 0.3

  1. ALAT = alanine aminotransferase; aPTTr = activated partial thromboplastin time ratio; ASAT = aspartate aminotransferase; AVP = arginine vasopressin; Creatinine rel = relative increase in creatinine concentrations from baseline; INR = international normalized ratio; NE = norepinephrine; TP = terlipressin.
  2. * P < 0.05 vs. baseline (significant time effect); † P < 0.05 vs. TP (significant group effect); ‡ P < 0.05 vs. AVP (significant group effect); § P < 0.05 vs. NE (significant group effect).
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Critical Care

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