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Table 5 Surrogate variables of organ function and injury

From: Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study

  Baseline 12 hours 24 hours 36 hours 48 hours
Creatinine
(mg/dL)
     
TP 2.5 ± 1 2.6 ± 1.2 2.8 ± 1.4 2.8 ± 1.3 2.8 ± 1.4
AVP 2.2 ± 1 2.4 ± 1.1 2.4 ± 1.2 2.5 ± 1.4 2.4 ± 1.2
NE 2.2 ± 1.6 2.6 ± 1.7 2.7 ± 1.7* 2.9 ± 1.8* 3.3 ± 2*
Creatinine, rel.
(%)
     
TP -- 4 ± 16 11 ± 23 13 ± 27 14 ± 35§
AVP -- 11 ± 17 12 ± 26 15 ± 31 10 ± 21§
NE -- 19 ± 23 23 ± 37 34 ± 48 54 ± 77†‡
Bilirubin, tot.
(mg/dL)
     
TP 1.2 ± 0.7 1 ± 0.5 1 ± 0.5 0.9 ± 0.3‡§ 0.9 ± 0.3‡§
AVP 1.6 ± 1.3 1.6 ± 1.2 1.8 ± 1.6 2.0 ± 2.0 2.3 ± 2.8
NE 1.6 ± 0.9 1.9 ± 0.8 2.0 ± 1.2 2.3 ± 1.7* 2.8 ± 2.5*
Bilirubin, dir.
(mg/dL)
     
TP 0.5 ± 0.3 0.5 ± 0.4 0.5 ± 0.3 0.4 ± 0.2§ 0.3 ± 0.1‡§
AVP 0.8 ± 0.9 1 ± 1.2 1.1 ± 1.4 1.1 ± 1.5 1.4 ± 1.9*
NE 0.8 ± 0.5 1.2 ± 0.8 1.2 ± 0.9 1.6 ± 1.7* 1.9 ± 2.1*
ASAT
(U/L)
     
TP 52 ± 26 52 ± 33 54 ± 35 53 ± 42 48 ± 34
AVP 63 ± 49 85 ± 57 79 ± 66 119 ± 163 91 ± 95
NE 72 ± 68 89 ± 115 95 ± 132 103 ± 146 90 ± 122
ALAT
(U/L)
     
TP 30 ± 14 34 ± 15 33 ± 14 35 ± 18 30 ± 13
AVP 45 ± 31 58 ± 42 63 ± 53 69 ± 67 81 ± 85
NE 43 ± 45 62 ± 80 68 ± 103 73 ± 114 63 ± 97
Amylase
(U/L)
     
TP 168 ± 97 148 ± 90 133 ± 79 127 ± 79 144 ± 124
AVP 165 ± 111 152 ± 100 143 ± 79 147 ± 110 123 ± 70
NE 203 ± 191 199 ± 182 217 ± 221 206 ± 212 172 ± 152
Lipase
(U/L)
     
TP 138 ± 145 125 ± 92 97 ± 64 144 ± 126 116 ± 91
AVP 133 ± 90 124 ± 68 127 ± 64 136 ± 72 134 ± 65
NE 134 ± 160 198 ± 282 120 ± 96 158 ± 162 115 ± 65
Troponine I
(ng/mL)
     
TP 0.31 ± 0.3 0.31 ± 0.51 0.22 ± 0.41 0.19 ± 0.35 0.18 ± 0.3
AVP 0.56 ± 1 0.84 ± 1.5 1.23 ± 2.4 1.37 ± 2.5 1.17 ± 2
NE 0.58 ± 0.9 0.66 ± 0.8 0.72 ± 0.75 0.69 ± 0.86 0.63 ± 1
Platelet count
(103 cells/μL)
     
TP 119 ± 68 103 ± 59 93 ± 59* 78 ± 48* 73 ± 41*
AVP 110 ± 56 102 ± 63 95 ± 53 95 ± 55 93 ± 50
NE 114 ± 64 102 ± 52 99 ± 58 94 ± 60 94 ± 69
INR      
TP 1.4 ± 0.2 1.4 ± 0.2 1.4 ± 0.2 1.4 ± 0.2 1.4 ± 0.2
AVP 1.5 ± 0.5 1.5 ± 0.3 1.5 ± 0.5 1.5 ± 0.4 1.5 ± 0.5
NE 1.5 ± 0.3 1.5 ± 0.3 1.4 ± 0.4 1.3 ± 0.2 1.4 ± 0.3
APTTr      
TP 1.7 ± 0.6 1.6 ± 0.5 1.6 ± 0.4 1.8 ± 0.6 1.7 ± 0.7
AVP 1.5 ± 0.5 1.5 ± 0.6 1.6 ± 0.7 1.6 ± 0.7 1.7 ± 0.7
NE 1.5 ± 0.2 1.4 ± 0.2 1.4 ± 0.2 1.4 ± 0.2 1.6 ± 0.3
  1. ALAT = alanine aminotransferase; aPTTr = activated partial thromboplastin time ratio; ASAT = aspartate aminotransferase; AVP = arginine vasopressin; Creatinine rel = relative increase in creatinine concentrations from baseline; INR = international normalized ratio; NE = norepinephrine; TP = terlipressin.
  2. * P < 0.05 vs. baseline (significant time effect); P < 0.05 vs. TP (significant group effect); P < 0.05 vs. AVP (significant group effect); § P < 0.05 vs. NE (significant group effect).