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Table 3 Oxygenation profile, acid-base variables and hemoglobin concentrations

From: Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study

  Baseline 12 hours 24 hours 36 hours 48 hours
PH
(-log10 c(H+))
     
TP 7.31 ± 0.1 7.32 ± 0.1 7.32 ± 0.1 7.34 ± 0.08 7.37 ± 0.08*
AVP 7.36 ± 0.09 7.35 ± 0.11 7.32 ± 0.12 7.34 ± 0.12 7.32 ± 0.11
NE 7.34 ± 0.1 7.34 ± 0.08 7.32 ± 0.08 7.31 ± 0.09 7.28 ± 0.12*
PaO 2 /FiO 2      
TP 176 ± 105 179 ± 82 189 ± 86 216 ± 95 220 ± 78
AVP 219 ± 118 231 ± 117 222 ± 129 211 ± 132 225 ± 133
NE 200 ± 97 216 ± 113 213 ± 101 194 ± 73 185 ± 85
PaO 2
(mmHg)
     
TP 113 ± 44 127 ± 45 141 ± 47 164 ± 66 175 ± 64
AVP 123 ± 36 140 ± 48 130 ± 49 127 ± 59 139 ± 58
NE 120 ± 46 124 ± 44 125 ± 31 123 ± 34 114 ± 49
pvO 2
(mmHg)
     
TP 36 ± 6 36 ± 6 36 ± 5 35 ± 5 36 ± 5
AVP 35 ± 6 38 ± 6 38 ± 5 38 ± 6 38 ± 6
NE 36 ± 7 38 ± 6 38 ± 6 39 ± 7 38 ± 6
SaO 2
(%)
     
TP 96 ± 4 97 ± 3 98 ± 2 99 ± 2 99 ± 2
AVP 97 ± 3 98 ± 3 98 ± 2 96 ± 4 98 ± 2
NE 97 ± 2 96 ± 7 98 ± 1 98 ± 2 96 ± 7
SvO 2
(%)
     
TP 60 ± 7 59 ± 11 60 ± 9 60 ± 8 63 ± 8
AVP 61 ± 12 65 ± 11 64 ± 7 63 ± 13 64 ± 12
NE 62 ± 10 66 ± 10 66 ± 9 66 ± 9 62 ± 12
DO 2 I
(mL/min/m)
     
TP 473 ± 105 468 ± 117 433 ± 92 393 ± 73 402 ± 70
AVP 464 ± 137 519 ± 189 550 ± 165 484 ± 123 520 ± 242
NE 460 ± 131 471 ± 157 482 ± 136 462 ± 136 467 ± 162
VO 2 I
(mL/min/m)
     
TP 184 ± 58 184 ± 49 171 ± 32 160 ± 43 152 ± 38
AVP 173 ± 51 173 ± 59 193 ± 65 168 ± 52 173 ± 51
NE 163 ± 41 147 ± 35 160 ± 57 153 ± 51 164 ± 67
O 2 -ER
(%)
     
TP 38 ± 6 40 ± 9 40 ± 8 41 ± 8 38 ± 8
AVP 39 ± 12 35 ± 9 35 ± 6 36 ± 11 37 ± 10
NE 37 ± 10 32 ± 6 34 ± 9 34 ± 9 36 ± 10
PaCO 2
(mmHg)
     
TP 45 ± 6 42 ± 6 41 ± 9 40 ± 8 38 ± 6
AVP 43 ± 9 40 ± 5 42 ± 4 41 ± 6 41 ± 6
NE 44 ± 9 43 ± 9 44 ± 8 44 ± 8 43 ± 9
ABE
(mmol/L)
     
TP -2.9 ± 5.1 -4.6 ± 4.2 -4.9 ± 4.6 -4.0 ± 4.2 -3.1 ± 4.2
AVP -1.8 ± 6.5 -2.8 ± 7.0 -3.7 ± 6.7 -1.6 ± 7.8 -4.1 ± 6.5
NE -2.5 ± 4.5 -2.5 ± 4.3 -3.5 ± 4.3 -4.2 ± 3.9 -6.2 ± 5.4*
Arterial lactate
(mmol/L)
     
TP 3.1 ± 1.8 2.9 ± 1.9 2.9 ± 2.0 3.4 ± 2.4 3.6 ± 3.0
AVP 3.0 ± 2.4 3.2 ± 2.3 3.4 ± 2.3 3.2 ± 2.3 3.4 ± 3.3
NE 3.1 ± 2.2 3.3 ± 2.8 3.4 ± 2.8 3.6 ± 2.4 4.3 ± 3.4*
Hemoglobin
(g/dL)
     
TP 8.6 ± 0.9 8.7 ± 0.7 8.4 ± 1.2 8.2 ± 0.6 8.1 ± 0.6
AVP 8.3 ± 0.9 8.7 ± 1.1 9 ± 1.1* 9 ± 1* 8.8 ± 0.9
NE 8.3 ± 0.8 8.7 ± 0.9 8.4 ± 0.5 8.5 ± 0.8 8.9 ± 1
  1. ABE = arterial base excess; AVP = arginine vasopressin; DO2I = oxygen delivery index; NE = norepinephrine; O2-ER = oxygen extraction rate; PaCO2 = partial pressure of arterial carbon dioxide; PaO2/FiO2 = ratio of oxygen tension over inspired oxygen concentration; PaO2 = partial pressure of arterial oxygen; pH = arterial pH; pvO2 = mixed venous oxygen tension; SaO2 = arterial oxygen saturation; SvO2 = mixed venous oxygen saturation; VO2I = oxygen consumption index; TP = terlipressin.
  2. * P < 0.05 vs. baseline (significant time effect); P < 0.05 vs. TP (significant group effect); P < 0.05 vs. AVP (significant group effect); § P < 0.05 vs. NE (significant group effect).