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Table 3 Comparison of the WA and CORE cohorts

From: Landmark survival as an end-point for trials in critically ill patients – comparison of alternative durations of follow-up: an exploratory analysis

  Sepsis Pneumonia Trauma
Variable WA
(n = 111)
CORE
(n = 1429)
P WA
(n = 82)
CORE
(n = 1066)
P WA
(n = 176)
CORE
(n = 2114)
P
Age, years (SD) 54.6 (16.9) 60.1 (17.9) 0.001 56.1 (15.7) 61.1 (17.8) 0.003 35.9 (16.27) 42.6 (19.3) 0.001
Male, number (%) 54 (48.6) 792 (55.4) 0.20 47 (57.3) 588 (55.2) 0.73 137 (77.8) 1599(75.6) 0.58
Median APACHE II score (IQR) 22.0 (11.0) 21.0 (13.7) 0.90 20 (9.3) 19 (10) 0.80 13.0 (9.8) 11.0 (10.0) 0.001
Median APACHE II predicted mortality, % (IQR) 45.2 (37.6) 41.6 (43.6) 0.78 35.5 (28.3) 32.2 (31.0) 0.80 6.3 (12.1) 6.2 (12.4) 0.12
Chronic respiratory disease, number (%) 2 (1.8) 126 (8.8) 0.006 8 (9.8) 206 (19.3) 0.04 1 (0.6) 58 (2.7) 0.08
Chronic cardiovascular disease, number (%) 1 (0.9) 140 (9.8) 0.001 1 (1.2) 93 (8.7) 0.01 0 (0) 43 (2.0) 0.07
Chronic renal disease, number (%) 3 (2.7) 105 (7.3) 0.08 3 (3.7) 27 (2.5) 0.47 0 (0) 3 (0.1) 1.00
Chronic liver disease, number (%) 0 (0) 59 (4.1) 0.02 0 (0) 25 (2.3) 0.25 0 (0) 12 (0.6) 0.62
Immunosuppressed state, number (%) 7 (6.3) 185 (12.9) 0.05 5 (6.1) 101 (9.4) 0.43 0 (0) 38 (1.8) 0.11
Median length of ICU stay, days (IQR) 5.1 (7.0) 2.4 (4.9) 0.001 7 (8.3) 3.61 (6.6) 0.001 4.0 (9.8) 2.0(4.7) 0.001
Median length of hospital stay, days (IQR) 18.0 (24.0) 9.9 (16.1) 0.001 15 (11.8) 11.4 (13.5) 0.01 18.0 (26.8) 8.0 (16.7) 0.001
ICU mortality, number (%)* 24 (21.6) 319 (23.0) 0.82 13 (15.9) 169 (16.2) 1.00 17 (9.7) 163 (8.0) 0.47
28-day mortality, number (%) 28 (23.4) 355 (27.9) 0.58 18 (22.0) 190 (20.2) 0.67 18 (10.2) 195 (9.7) 0.79
Hospital mortality, number (%)* 35 (31.5) 417 (30.7) 0.83 20 (24.4) 230 (23.0) 0.79 20 (11.4) 210 (10.5) 0.70
  1. # P values were generated by either Mann-Whitney or chi-squared test.
  2. * Intensive care unit (ICU) and hospital mortality outcome of CORE cohort was available only in 2031 and 2010 cases, respectively.
  3. APACHE = Acute Physiology and Chronic Health Evaluation; IQR = interquartile range; SD = standard deviation.