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Table 2 Single variable and multivariable analysis for prediction of death and survival (* P < 0.05)

From: Landmark survival as an end-point for trials in critically ill patients – comparison of alternative durations of follow-up: an exploratory analysis

Single variable analysis
Diagnosis Variables 28 day 90 day 180 day All mortality Time
to death (TTD)
TTD from
ICU discharge
Pneumonia Age 1.08
(1.03–1.13)*
1.09
(1.04–1.14)*
1.08
(1.04–1.13)*
1.07
(1.03–1.10)*
1.06
(1.03–1.09)*
1.05
(1.01–1.09)*
  APACHE score 1.11
(1.02–1.21)*
1.08
(1.01–1.17)*
1.09
(1.02–1.18)*
1.07
(1.00–1.15)*
1.06
(1.01–1.11)*
1.04
(0.97–1.11)
  Charlson 1.07
(0.88–1.29)
1.12
(0.94–1.33)
1.13
(0.95–1.35)
1.11
(0.93–1.33)
1.06
(0.96–1.18)
1.09
(0.96–1.22)
  GCS 1.30
(0.82–2.05)
1.01
(0.81–1.26)
1.00
(0.81–1.23)
1.00
(0.82–1.23)
1.01
(0.87–1.19)
0.93
(0.80–1.09)
  Organ score 1.44
(1.05–1.97)*
1.39
(1.04–1.84)*
1.56
(1.16–2.11)*
1.41
(1.07–1.86)*
1.30
(1.08–1.57)*
1.25
(0.96–1.62)
  Male 0.68
(0.22–2.05)
0.74
(0.28–1.96)
1.11
(0.44–2.82)
1.11
(0.46–2.68)
1.03
(0.52–2.06)
1.19
(0.47–2.99)
Sepsis Age 1.01
(0.99–1.04)
1.02
(1.00–1.05)
1.02
(1.00–1.05)
1.03
(1.01–1.06)*
1.02
(1.00–1.04)*
1.05
(1.02–1.08)*
  APACHE score 1.07
(1.01–1.13)*
1.07
(1.02–1.13)*
1.06
(1.00–1.11)*
1.05
(1.00–1.11)
1.05
(1.01–1.09)*
1.04
(0.99–1.10)
  Charlson 1.04
(0.87–1.23)
1.00
(0.85–1.18)
1.07
(0.91–1.25)
1.15
(0.98–1.35)
1.08
(0.98–1.20)
1.15
(1.02–1.30)*
  GCS 0.94
(0.84–1.04)
0.89
(0.8–0.99)*
0.9
(0.81–1.01)
0.9
(0.81–1.00)
0.93
(0.87–1.00)*
0.92
(0.84–1.00)
  Organ score 1.67
(1.26–2.23)*
1.42
(1.12–1.8)*
1.38
(1.09–1.74)*
1.38
(1.10–1.73)*
1.28
(1.09–1.50)*
1.14
(0.92–1.41)
  Male 0.77
(0.33–1.81)
1.00
(0.45–2.2)
1.07
(0.49–2.33)
1.06
(0.5–2.25)
1
(0.56–1.81)
1.03
(0.46–2.30)
Trauma Age 1.00
(0.97–1.03)
1.00
(0.97–1.03)
1.01
(0.98–1.04)
1.01
(0.99–1.04)
1.01
(0.99–1.03)
1.03
(1.00–1.07)
  APACHE score 1.28
(1.16–1.41)*
1.28
(1.16–1.41)*
1.25
(1.15–1.36)*
1.22
(1.13–1.31)*
1.18
(1.12–1.24)*
1.13
(1.05–1.22)*
  Charlson 0.87
(0.32–2.35)
0.87
(0.32–2.35)
0.85
(0.31–2.32)
0.72
(0.24–2.13)
0.74
(0.25–2.18)
0
(0–.)
  GCS 0.62
(0.49–0.79)*
0.62
(0.49–0.79)*
0.70
(0.59–0.83)*
0.77
(0.69–0.87)*
0.78
(0.70–0.88)*
0.87
(0.76–0.99)*
  Organ score 1.75
(1.30–2.36)*
1.75
(1.30–2.36)*
1.73
(1.29–2.31)*
1.66
(1.28–2.16)*
1.46
(1.22–1.75)*
1.44
(1.10–1.87)*
  Male 0.68
(0.19–2.47)
0.68
(0.19–2.47)
0.63
(0.17–2.28)
0.44
(0.12–1.54)
0.47
(0.14–1.62)
0.69
(0.15–3.25)
Multivariable analysis
Diagnosis Variables 28 day 90 day 180 day All mortality Time
to death (TTD)
TTD from
ICU discharge
Pneumonia Age 1.08
(1.03–1.13)*
1.09
(1.04–1.14)*
1.08
(1.03–1.13)*
1.07
(1.03–1.10)*
1.05
(1.02–1.09)*
1.05
(1.01–1.09)*
  Organ score    1.54
(1.11–2.15)*
  1.26
(1.03–1.55)*
 
Sepsis Age 1.04
(1.01–1.07)*
1.03
(1.00–1.05)*
  1.04
(1.01–1.07)*
1.03
(1.01–1.05)*
1.05
(1.02–1.08)*
  Organ score 1.45
(1.13–1.85)*
1.47
(1.14–1.89)*
1.38
(1.09–1.74)*
1.45
(1.13–1.85)*
1.31
(1.11–1.54)*
 
Trauma APACHE score 1.28
(1.16–1.41)*
1.28
(1.16–1.41)*
1.25
(1.15–1.36)*
1.22
(1.13–1.31)*
1.18
(1.12–1.24)*
1.13
(1.05–1.22)*
  1. APACHE = Acute Physiology and Chronic Health Evaluation; GCS = Glasgow Coma Scale.