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Table 2 Single variable and multivariable analysis for prediction of death and survival (* P < 0.05)

From: Landmark survival as an end-point for trials in critically ill patients – comparison of alternative durations of follow-up: an exploratory analysis

Single variable analysis

Diagnosis

Variables

28 day

90 day

180 day

All mortality

Time

to death (TTD)

TTD from

ICU discharge

Pneumonia

Age

1.08

(1.03–1.13)*

1.09

(1.04–1.14)*

1.08

(1.04–1.13)*

1.07

(1.03–1.10)*

1.06

(1.03–1.09)*

1.05

(1.01–1.09)*

 

APACHE score

1.11

(1.02–1.21)*

1.08

(1.01–1.17)*

1.09

(1.02–1.18)*

1.07

(1.00–1.15)*

1.06

(1.01–1.11)*

1.04

(0.97–1.11)

 

Charlson

1.07

(0.88–1.29)

1.12

(0.94–1.33)

1.13

(0.95–1.35)

1.11

(0.93–1.33)

1.06

(0.96–1.18)

1.09

(0.96–1.22)

 

GCS

1.30

(0.82–2.05)

1.01

(0.81–1.26)

1.00

(0.81–1.23)

1.00

(0.82–1.23)

1.01

(0.87–1.19)

0.93

(0.80–1.09)

 

Organ score

1.44

(1.05–1.97)*

1.39

(1.04–1.84)*

1.56

(1.16–2.11)*

1.41

(1.07–1.86)*

1.30

(1.08–1.57)*

1.25

(0.96–1.62)

 

Male

0.68

(0.22–2.05)

0.74

(0.28–1.96)

1.11

(0.44–2.82)

1.11

(0.46–2.68)

1.03

(0.52–2.06)

1.19

(0.47–2.99)

Sepsis

Age

1.01

(0.99–1.04)

1.02

(1.00–1.05)

1.02

(1.00–1.05)

1.03

(1.01–1.06)*

1.02

(1.00–1.04)*

1.05

(1.02–1.08)*

 

APACHE score

1.07

(1.01–1.13)*

1.07

(1.02–1.13)*

1.06

(1.00–1.11)*

1.05

(1.00–1.11)

1.05

(1.01–1.09)*

1.04

(0.99–1.10)

 

Charlson

1.04

(0.87–1.23)

1.00

(0.85–1.18)

1.07

(0.91–1.25)

1.15

(0.98–1.35)

1.08

(0.98–1.20)

1.15

(1.02–1.30)*

 

GCS

0.94

(0.84–1.04)

0.89

(0.8–0.99)*

0.9

(0.81–1.01)

0.9

(0.81–1.00)

0.93

(0.87–1.00)*

0.92

(0.84–1.00)

 

Organ score

1.67

(1.26–2.23)*

1.42

(1.12–1.8)*

1.38

(1.09–1.74)*

1.38

(1.10–1.73)*

1.28

(1.09–1.50)*

1.14

(0.92–1.41)

 

Male

0.77

(0.33–1.81)

1.00

(0.45–2.2)

1.07

(0.49–2.33)

1.06

(0.5–2.25)

1

(0.56–1.81)

1.03

(0.46–2.30)

Trauma

Age

1.00

(0.97–1.03)

1.00

(0.97–1.03)

1.01

(0.98–1.04)

1.01

(0.99–1.04)

1.01

(0.99–1.03)

1.03

(1.00–1.07)

 

APACHE score

1.28

(1.16–1.41)*

1.28

(1.16–1.41)*

1.25

(1.15–1.36)*

1.22

(1.13–1.31)*

1.18

(1.12–1.24)*

1.13

(1.05–1.22)*

 

Charlson

0.87

(0.32–2.35)

0.87

(0.32–2.35)

0.85

(0.31–2.32)

0.72

(0.24–2.13)

0.74

(0.25–2.18)

0

(0–.)

 

GCS

0.62

(0.49–0.79)*

0.62

(0.49–0.79)*

0.70

(0.59–0.83)*

0.77

(0.69–0.87)*

0.78

(0.70–0.88)*

0.87

(0.76–0.99)*

 

Organ score

1.75

(1.30–2.36)*

1.75

(1.30–2.36)*

1.73

(1.29–2.31)*

1.66

(1.28–2.16)*

1.46

(1.22–1.75)*

1.44

(1.10–1.87)*

 

Male

0.68

(0.19–2.47)

0.68

(0.19–2.47)

0.63

(0.17–2.28)

0.44

(0.12–1.54)

0.47

(0.14–1.62)

0.69

(0.15–3.25)

Multivariable analysis

Diagnosis

Variables

28 day

90 day

180 day

All mortality

Time

to death (TTD)

TTD from

ICU discharge

Pneumonia

Age

1.08

(1.03–1.13)*

1.09

(1.04–1.14)*

1.08

(1.03–1.13)*

1.07

(1.03–1.10)*

1.05

(1.02–1.09)*

1.05

(1.01–1.09)*

 

Organ score

  

1.54

(1.11–2.15)*

 

1.26

(1.03–1.55)*

 

Sepsis

Age

1.04

(1.01–1.07)*

1.03

(1.00–1.05)*

 

1.04

(1.01–1.07)*

1.03

(1.01–1.05)*

1.05

(1.02–1.08)*

 

Organ score

1.45

(1.13–1.85)*

1.47

(1.14–1.89)*

1.38

(1.09–1.74)*

1.45

(1.13–1.85)*

1.31

(1.11–1.54)*

 

Trauma

APACHE score

1.28

(1.16–1.41)*

1.28

(1.16–1.41)*

1.25

(1.15–1.36)*

1.22

(1.13–1.31)*

1.18

(1.12–1.24)*

1.13

(1.05–1.22)*

  1. APACHE = Acute Physiology and Chronic Health Evaluation; GCS = Glasgow Coma Scale.