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Table 2 Demographic data and clinical characteristics grouped according to adrenal function

From: Critical illness-related corticosteroid insufficiency in patients with severe acute biliary pancreatitis: a prospective cohort study

 

All patients

(n = 32)

Adrenal insufficiency

(n = 11)

Normal adrenal function

(n = 21)

P value

Age (years)

68 (55 to 80)

73 (58 to 80)

68 (55 to 81)

NS (0.685)

Gender (M/F)

12/20

4/7

8/13

NS (0.923)

ICU mortality (%)

6 (18.8)

5 (45.5)

1 (4.8)

0.011

Hospital mortality (%)

7 (21.9)

5 (45.5)

2 (9.5)

0.032

BUN (mg/dl)

15.5 (10.5 to 36.5)

23 (12 to 45)

15 (8.5 to 23.5)

NS (0.293)

Serum creatinine (mg/dl)

1.1 (0.6 to 1.9)

2.5 (1.1 to 3.7)

0.9 (0.6 to 1.3)

0.003

Bilirubin (mg/dl)

1.6 (0.8 to 3.2)

5.1 (1.9 to 9.6)

1.4 (0.7 to 2.0)

0.004

Albumin (g/l)

2.8 (2.4 to 3)

2.8 (2.4 to 2.8)

2.8 (2.2 to 3.1)

NS (0.839)

INR

1.2 (1.2 to 1.4)

1.3 (1.2 to 1.5)

1.2 (1.2 to 1.3)

NS (0.568)

MAP (mmHg)

79 (60 to 90)

58 (57 to 60)

84 (79 to 93)

< 0.001

SOFA score on the day of SST

5 (3 to 9)

11 (7 to 15)

4 (2 to 6)

< 0.001

APACHE II score on the day of SST

15 (10 to 20)

20 (10 to 27)

15 (11 to 18)

0.018

Ranson score

5 (3 to 6)

7 (5 to 9)

4 (3 to 5)

< 0.001.

Necrosis (%)

20 (62.5)

11 (100)

9 (42.9)

0.002

Bacteremia (%)

14 (43.8)

9 (81.8)

5 (23.8)

0.003

Number of organ dysfunction on the day of SST

2 (1 to 3)

4 (2.5 to 5)

1 (1 to 2)

< 0.001

   Respiratory dysfunction (%)

23 (71.9)

9 (81.8)

14 (66.7)

NS (0.441)

   Coagulation dysfunction (%)

7 (21.9)

7 (63.6)

0 (0)

< 0.001

   CV dysfunction (%)

10 (31.3)

9 (81.8)

1 (4.8)

< 0.001

   CNS dysfunction (%)

14 (43.8)

6 (54.5)

8 (38.1)

NS (0.465)

   Renal dysfunction (%)

12 (37.5)

7 (63.6)

5 (23.8)

0.027

  1. APACHE = Acute Physiology and Chronic Health Evaluation; BUN = blood urea nitrogen; CIRCI = critical illness related corticosteroid insufficiency; CNS = central nervous system; CV = cardiovascular; F = female; ICU = intensive care unit; INR = international normalized ratio; M = male; MAP = mean arterial pressure; NS = not significant; SOFA = sequential organ failure assessment; SST = short corticotropin stimulation test.