S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review

Table 6 Values of cutoff points and predictive accuracy for no-return to independent daily life

	on admission	Day 1	24 hours	Day 2	48 hours	Day 3
Authors	cut/spe/sen/acc	cut/spe/sen/acc	cut/spe/sen/acc	cut/spe/sen/acc	cut/spe/sen/acc	cut/spe/sen/acc
NSE
Tiainen and colleagues (hypothermia)	-	-	(31)/96/22/76	(26)/96/30/79	(25)/96/25/77	-
Tiainen and colleagues (normothermia)	-	-	(13)/100/59/80	(13)/100/63/82	(9)/100/76/88	-
Rosen and colleagues	-	(25)/100/14/44	-	(23)/100/34/59	-	(13)/100/44/69
Bottiger and colleagues	NM	-	NM	-	NM	-
Schoerkhuber and colleagues	NM	(39)/100/17/59	(40)/100/8/55	-	(25)/100/48/75	-
Schoerkhuber and colleagues	NM	(15)/72/70/71	(18)/80/56/68	-	(16)/79/72/76	-
S-100B
Tiainen M and colleagues (hypothermia)	-	-	(0.21)/100/30/81	(0.2)/96/20/76	(0.23)/96/22/76	-
Tiainen M and colleagues (normothermia)	-	-	(0.19)/100/59/80	(0.5)/100/18/59	(0.12)/100/88/94	-
Mussack and colleagues	NM	(0.76)/100/54/62	-	-	-	-
Rosen and colleagues	-	(0.4)/85/62/70	-	(0.2)/100/67/80	-	(0.19)/100/40/66
Bottiger and colleagues	NM	-	NM	-	NM	-

Values in bold are the results of our calculation. cut = values of cutoff points (ng/mL); spe = specificity (%); sen = sensitivity (%); acc = accuracy (%).
NM = not mentioned for cutoff values and predictive accuracy; NSE = neuron specific enolase.

ISSN: 1364-8535