S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review

Table 4 Values of cutoff points and predictive accuracy for remained coma

	on admission	Day 1	24 hours	Day 2	48 hours	Day 3
Authors	cut/spe/sen/acc	cut/spe/sen/acc	cut/spe/sen/acc	cut/spe/sen/acc	cut/spe/sen/acc	cut/spe/sen/acc
NSE
Reisinger and colleagues	NM	NM	-	NM	-	NM
Prohl and colleagues	-	(29)/100/33/78	-	(32)/100/33/78	-	(28)/100/67/89
Zandbergen and colleagues	-	-	NM	-	NM	-
Rech and colleagues	-	-	(60)/100/35/49	-	-	-
Pfeifer and colleagues	-	NM	-	NM	-	(65)/96/40/56
Meynaar and colleagues	NM	-	NM	-	NM	-
Zingler and colleagues	(48)/100/53/70	(43)/100/91/94	-	(91)/100/75/84	-	-
Martens [31]	-	-	(20)/89/51/68	-	-	-
Fogel and colleagues	(33)/100/25/56	(33)/100/60/77	-	(33)/100/63/78	-	(33)/100/65/80
Martens [34]	-	-	(18)/67/74/71	-	-	-
Bassetti and colleagues	-	NM	NM	-	-	-
Stelzl and colleagues	(18)/100/40/67	(17)/100/83/92	(21)/100/100/100	(29)/100/100/100	(36)/100/100/100	(24)/100/100/100
Karkela and colleagues	NM	-	NM	-	-	-
Dauberschmidt and colleagues	(11)/100/43/56	(5)/100/50/60	-	(5)/100/67/78	-	(5)/100/71/80
Roine and colleagues	-	-	(17)/98/40/80	-	-	-
S-100B
Zandbergen and colleagues	-	-	NM	-	NM	-
Prohl and colleagues	-	(2.1)/100/17/72	-	(1.8)/100/17/72	-	(1.2)/100/33/78
Pfeifer and colleagues	-	NM	-	NM	-	(1.5)/96/34/51
Zingler and colleagues	(5.2)/100/35/59	(0.8)/100/64/77	-	(0.5)/100/75/84	-	-
Hachimi-Idrissi and colleagues	(0.7)/85/67/78	-	(0.7)/88/100/93	-	-	-
Martens [31]	-	-	(0.7)/96/55/73	-	-	-

Values in bold are the results of our calculation. cut = values of cutoff points (ng/mL); spe = specificity (%); sen = sensitivity (%); acc = accuracy (%).
NM = not mentioned for cutoff values and predictive accuracy; NSE = neuron specific enolase.

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