S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review

Table 3 Comparison of values for biomarkers between remained coma and regained consciousness

Authors	Year	Ref	n	on admission	Day 1	24 hours	Day 2	48 hours	Day 3
NSE
Reisinger and colleagues	2007	[21]	227	NM	NM	-	NM	-	NM
Prohl and colleagues	2007	[39]	80	-	P < 0.01	-	P < 0.01	-	P < 0.01
Zandbergen and colleagues	2006	[22]	407	-	-	NM	-	NM	-
Rech and colleagues	2006	[23]	45	-	-	P < 0.01	-	-	-
Pfeifer and colleagues	2005	[25]	97	-	P < 0.05-	-	P < 0.05	-	P < 0.05
Meynaar and colleagues	2003	[27]	110	NS	-	P < 0.01	-	P < 0.01	-
Zingler and colleagues	2003	[28]	27	NS	P < 0.05	-	P < 0.05-	-	-
Martens and colleagues	1998	[31]	64	-	-	P < 0.01	-	-	-
Fogel and colleagues	1997	[32]	50	P < 0.01	P < 0.01	-	P < 0.01	-	P < 0.01
Martens	1996	[34]	52	-	-	P < 0.01	-	-	-
Bassetti and colleagues	1996	[33]	60	-	NM	NM	-	-	-
Stelzl and colleagues	1995	[35]	13	NS	*P < 0.05*	*P < 0.05*	*P < 0.05*	*P < 0.05*	*P < 0.05*
Karkela and colleagues	1993	[36]	20	NS	-	NS	-	-	-
Dauberschmidt and colleagues	1991	[37]	18	NS	NS	-	NS	-	NS
Roine and colleagues	1989	[38]	75	-	-	P < 0.01	-	-	-
S-100B
Prohl and colleagues	2007	[39]	80	-	P < 0.01	-	P < 0.01	-	P < 0.01
Zandbergen and colleagues	2006	[22]	407	-	-	NM	-	NM	-
Pfeifer and colleagues	2005	[25]	97	-	NS	-	P < 0.05	-	P < 0.05
Zingler and colleagues	2003	[28]	27	P < 0.05	P < 0.01	-	P < 0.05	-	-
Hachimi-Idrissi and colleagues	2002	[16]	58	P < 0.01	-	P < 0.01	-	-	-
Martens and colleagues	1998	[31]	64	-	-	P < 0.01	-	-	-

Values in bold are the results of our calculation. NM = not mentioned for statistical comparison; NS = not significance; NSE = neuron specific enolase; Ref = references.

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