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Table 3 Risk factors for hospital mortality on ICU patients with candidaemia initially treated with fluconazole

From: Determinants of mortality in non-neutropenic ICU patients with candidaemia

Variable Dying patients, n (%) Surviving patients, n (%) Univariate analysis* Multivariate analysis**
    Unadjusted HR (95% CI) P Adjusted HR (95% CI) P
Age    1.03 (1.01 to 1.05) 0.001 1.03 (1.01 to 1.05) 0.002
Haemodialysis receipt 10/48 (21%) 4/45 (9%) 1.65 (0.82 to 3.32) 0.16 2.12 (1.03 to 4.35) 0.04
TPN receipt 30/48 (63%) 15/45 (33%) 1.90 (1.06 to 3.42) 0.03   
Non-multitrauma patient 47/48 (98%) 33/45 (73%) 9.35 (1.29 to 67.84) 0.03   
Ventilation day 1 40/48 (83%) 34/45 (76%) 1.28 (0.60 to 2.75) 0.52   
Candida glabrata or Candida krusei 11/48 (23%) 3/45 (7%) 2.31 (1.17 to 4.56) 0.02   
Time to fluconazole initiation 1.80 ± 1.29 days 2.51 ± 1.74 days 0.80 (0.65 to 0.98) 0.03   
Fluconazole MIC (log10 transformed) 0.24 ± 0.74 0.10 ± 0.68 1.31 (0.90 to 1.90) 0.16   
Fluconazole dose (log10 transformed) 2.66 ± 0.22 2.62 ± 0.21 1.89 (0.52 to 6.82) 0.33   
Fluconazole dose: MIC (log10 transformed) 2.33 ± 0.22 2.45 ± 0.72 0.77 (0.54 to 1.11) 0.16   
  1. CI = confidence interval; HR = hazard ratio; ICU = intensive care unit; MIC = minimum inhibitory concentration; TPN = total parenteral nutrition.