Table 2 Risk factors for hospital mortality on entire ICU cohort with candidaemia
From: Determinants of mortality in non-neutropenic ICU patients with candidaemia
Variable | Dying patients* | Surviving patients* | Univariate analysis** | Multivariate analysis† | ||
|---|---|---|---|---|---|---|
Unadjusted HR (95% CI) | P | Adjusted HR (95% CI)†† | P | |||
Male sex | 55/97 (57%) | 45/76 (59%) | 1.00 (0.67 to 1.49) | 0.99 | ||
Age | 63.3 ± 16.7 years | 51.1 ± 19.2 years | 1.03 (1.01 to 1.04) | <0.001 | 1.03 (1.01 to 1.4) | <0.001 |
Antifungal agents prior to diagnosis | 10/96 (10%) | 6/76 (8%) | 1.03 (0.53 to 1.98) | 0.93 | ||
Non-receipt of antifungal agents after diagnosis | 20/97 (21%) | 5/76 (7%) | 5.17 (3.08 to 8.68) | <0.001 | 7.90 (3.73 to 16.71) | <0.001 |
Candida albicans | 43/97 (44%) | 26/76 (34%) | 0.73 (0.49 to 1.10) | 0.13 | ||
Vascular access device removed or not in place | 55/80 (69%) | 64/79 (84%) | 0.41 (0.26 to 0.67) | <0.001 | ||
TPN receipt | 53/96 (55%) | 26/76 (34%) | 1.52 (1.02 to 2.28) | 0.04 | ||
Haemodialysis | 23/97 (24%) | 8/76 (11%) | 1.66 (1.04 to 2.66) | 0.03 | ||
Corticosteroid receipt | 33/97 (34%) | 20/76 (26%) | 1.36 (0.89 to 2.07) | 0.17 | ||
Non-multitrauma patient | 93/97 (96%) | 60/76 (79%) | 3.25 (1.19 to 8.87) | 0.02 | 6.97 (1.64 to 29.67) | 0.009 |
Recent surgery | 71/97 (73%) | 47/76 (62%) | 1.24 (0.79 to 1.94) | 0.35 | ||
Other healthcare related infections | 73/97 (75%) | 55/76 (72%) | 0.85 (0.53 to 1.35) | 0.49 | ||
Ventilation at day 1 | 82/96 (85%) | 55/76 (72%) | 1.51 (0.86 to 2.67) | 0.15 | 4.03 (1.93 to 8.41) | <0.001 |
Sepsis at day 1 | 86/97 (89%) | 60/76 (79%) | 1.33 (0.71 to 2.49) | 0.37 | ||
Time to initiation of systemic antifungal | 2.0 ± 1.3 days | 2.3 ± 1.6 days | 0.88 (0.75 to 1.04) | 0.13 | ||