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Table 1 In vitro antifungal susceptibility of Candida species isolated from ICU-acquired candidaemia episodes

From: Determinants of mortality in non-neutropenic ICU patients with candidaemia

Agent MIC* Candida albicans (n = 106) Candida glabrata (n = 32) Candida krusei (n = 7) Candida parapsilosis (n = 14) Candida tropicalis (n = 10)
AMB MIC50 0.125 0.25 0.25 0.5 0.5
  MIC90 0.25 0.5 0.5 0.5 0.5
5FC MIC50 0.125 0.03 8 0.125 0.06
  MIC90 0.5 0.03 16 0.25 0.125
FLU MIC50 1 32 64 2 1
  MIC90 2 64 >64 4 4
ITR MIC50 0.06 2 0.5 0.25 0.25
  MIC90 0.125 16 0.5 0.5 0.5
VOR MIC50 0.016 0.5 0.5 0.06 0.06
  MIC90 0.03 1 0.5 0.25 0.5
POS MIC range (no. tested) 0.008 to 0.06 (16) 0.03 to 8 (7) 0.125 (1) - 0.008 to 0.06 (4)
CAS MIC range (no. tested) 0.03 to 0.25 (27) 0.06 to 0.25 (11) 0.25 to 1 (3) 0.125 (1) 0.06 to 0.5 (7)
  1. AMB = amphotericin B; CAS = caspofungin; 5FC = 5-flucytosine; FLU = fluconazole; ITR = itraconazole; POS = posaconazole; MIC = minimum inhibitory concentration (μg/mL); VOR = voriconazole.