Table 3 Parameters of visceral organ (liver, kidney) hemodynamics, acid-base status and organ function in the control (n = 12, n = 11 at 24 hours of peritonitis) and AVP (n = 12) groups

Portal vein flow (mL/kg/min)

Control

18 (15 to 22)

29 (21 to 31)^b

29 (24 to 34)^b

26 (24 to 30)^b

AVP

18 (16 to 20)

24 (20 to 31)^b

22 (16 to 27)

20 (16 to 24)

Hepatic artery flow (mL/kg/min)

Control

1.7 (0.4 to 2.1)

1.4 (0.9 to 2.9)

1.6 (1.3 to 3.5)

2.1 (1.1 to 3.6)^b

AVP

0.6 (0.2 to 1.6)

1.6 (0.2 to 3.2)^b

1.9 (0.3 to 3.3)^b

3.0 (0.3 to 5.5)^b

Hepatic O₂ delivery

(mL/kg/min)

Control

1.0 (0.9 to 1.5)

2.9 (2.5 to 3.7)^b

3.0 (2.0 to 3.5)^b

2.6 (1.8 to 3.1)^b

AVP

1.2 (1.0 to 1.5)

2.5 (1.9 to 3.0)^b

2.2 (1.7 to 3.0)^b

2.3 (1.4 to 2.7)^b

Portal vein O₂ saturation (%)

Control

58 (55 to 64)

78 (76 to 81)^b

77 (71 to 79)^b

72 (67 to 74)^b

AVP

60 (55 to 63)

78 (68 to 83)^b

72 (65 to 75)^b

69 (63 to 71)^b

Hepatic vein O₂ saturation (%)

Control

AVP

25 (24 to 72)

63 (54 to 65)^b

58 (52 to 65)^b

53 (44 to 56)^b

30 (20 to 55)

66 (50 to 70)^b

54 (42 to 61)^b

55 (50 to 58)^b

Portal drained viscera O₂ extraction (%)

Control

AVP

40 (37 to 46)

21 (18 to 24)^b

21 (18 to 25)^b

27 (24 to 34)^b

43 (37 to 44)

22 (17 to 35)^b

22 (19 to 31)^b

30 (25 to 34)^b

Hepatic O₂ uptake

Control

0.6 (0.4 to 0.8)

0.6 (0.4 to 0.9)

0.7 (0.5 to 1.1)

0.6 (0.4 to 0.8)

(mL/kg/min)

AVP

0.6 (0.5 to 0.9)

0.8 (0.5 to 0.9)

0.7 (0.4 to 1.0)

0.5 (0.3 to 0.7)

Portal vein

Control

10 (9 to 12)

14 (12 to 15)

15 (13 to 17)

16 (13 to 18)^a

lactate/pruvate ratio

AVP

11 (10 to 12)

13 (11 to 15)

14 (13 to 15)

15 (13 to 17)^a

Hepatic vein

Control

9 (8 to 10)

12 (10 to 15)

13 (12 to 15)

14 (12 to 18)^a

lactate/pruvate ratio

AVP

8 (7 to 12)

12 (10 to 15)

11 (10 to 16)

13 (11 to 16)^a

Portal vein pH

Control

7.49 (7.46 to 7.52)

7.46 (7.42 to 7.48)

7.41 (7.38 to 7.45)^b

7.37 (7.33 to 7.42)^b

AVP

7.48 (7.43 to 7.51)

7.47 (7.44 to 7.49)^b

7.44 (7.39 to 7.47)^b

7.42 (7.37 to 7.43)^b

Hepatic vein pH

Control

7.49 (7.47 to 7.53)

7.48 (7.43 to 7.49)

7.43 (7.40 to 7.46)^b

7.39 (7.33 to 7.44)^b

AVP

7.49 (7.44 to 7.54)

7.47 (7.44 to 7.50)

7.43 (7.39 to 7.48)^b

7.44 (7.40 to 7.46)

Portal vein base excess

(mmol/L)

Control

10.8 (9.5 to 12.5)

10.2 (8.1 to 11.2)^b

6.5 (3.0 to 8.2)^b

4.8 (0.1 to 6.2)^b

AVP

9.8 (7.8 to 12.4)

9.2 (7.3 to 10.4)

9.5 (6.0 to 10.6)

8.9 (3.0 to 11.0)^a

Hepatic vein base excess (mmol/L)

Control

12.6 (10.5 to 14.2)

11.1 (7.9 to 12.2)^b

7.6 (5.1 to 8.9)^b

5.8 (0.5 to 7.4)^b

AVP

11.6 (10.1 to 14.8)

10.5 (8.5 to 12.2)^b

9.8 (4.5 to 11.1)^b

9.0 (3.8 to 11.8)^b

ICG plasma

Control

20 (19 to 23)

17 (13 to 31)

14 (10 to 34)

13 (8 to 22)^b

disappearance rate (%/min)

AVP

15 (11 to 19)

14 (10 to 18)

13 (8 to 15)

12 (12 to 15)

Urine output

(mL/kg/h)

Control

5.4 (4.1 to 7.2)

3.2 (2.3 to 4.8)^b

AVP

6.7 (5.9 to 8.0)

5.6 (4.6 to 8.6)^a

Creatinine clearance

(mL/min)

Control

80 (67 to 88)

64 (35 to 85)^c

AVP

79 (60 to 98)

61 (44 to 73)^c

Fractional Na⁺ excretion (%)

Control

AVP

5.6 (4.8 to 7.7)

3.0 (2.5 to 5.1)

8.3 (6.4 to 10.0)^a

9.5 (7.2 to 10.7)^a