| Stage 1 | Stage 2 | P 2,1 | Stage 3 | P 3,1 | Stage 4 | P 4,1 |
---|---|---|---|---|---|---|---|
Responders | Â | Â | Â | Â | Â | Â | Â |
   SV (ml) | 68 ± 25 | 82 ± 30 | 0.001 | 70 ± 26 | 0.76 | 86 ± 31 | 0.004 |
   SV % change from stage 1 |  | 21.0 ± 12.5 |  | 2.4 ± 7.8 |  | 26.3 ± 14.2 |  |
   CO (L/min) | 6.8 ± 2.5 | 8.0 ± 2.8 | 0.03 | 6.9 ± 2.6 | 0.89 | 8.3 ± 3.1 | 0.009 |
   FTc (ms) | 363 ± 70 | 380 ± 68 | 0.22 | 356 ± 59 | 0.62 | 393 ± 66 | 0.03 |
   MAP (mmHg) | 68 ± 13 | 72 ± 11 | 0.11 | 70 ± 11 | 0.41 | 71 ± 16 | 0.38 |
   Heart rate (beats/min) | 101 ± 20 | 99 ± 21 | 0.64 | 100 ± 21 | 0.81 | 99 ± 20 | 0.61 |
   Pulse pressure (mmHg) | 42 ± 14 | 45 ± 14 | 0.23 | 45 ± 13 | 0.30 | 49 ± 16 | 0.02 |
   CVP (mmHg) | 7.8 ± 4.9 |  |  |  |  | 9.9 ± 3.9 | 0.10 |
Non-responders | Â | Â | Â | Â | Â | Â | Â |
   SV (ml) | 87 ± 30 | 91 ± 33 | 0.58 | 88 ± 30 | 0.99 | 90 ± 31 | 0.62 |
   SV % change from stage 1 |  | 3.2 ± 10.4 |  | 0.3 ± 5.9 |  | 3.5 ± 8.6 |  |
   CO (L/min) | 8.0 ± 2.9 | 8.4 ± 3.5 | 0.46 | 7.9 ± 2.9 | 0.97 | 8.2 ± 3.1 | 0.71 |
   FTc (ms) | 398 ± 66 | 404 ± 78 | 0.66 | 399 ± 68 | 0.89 | 405 ± 68 | 0.58 |
   MAP (mmHg) | 74 ± 14 | 74 ± 16 | 0.95 | 73 ± 14 | 0.72 | 74 ± 16 | 0.97 |
   Heart rate (beats/min) | 93 ± 20 | 94 ± 21 | 0.84 | 93 ± 20 | 0.91 | 92 ± 20 | 0.75 |
   Pulse pressure (mmHg) | 48 ± 15 | 49 ± 17 | 0.97 | 49 ± 18 | 0.89 | 49 ± 19 | 0.83 |
   CVP (mmHg) | 8.1 ± 4.8 |  |  |  |  | 11.3 ± 5.5 | 0.01 |