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Table 1 Systemic hemodynamics, respiration, hemoglobin, and biochemical markers of the different groups

From: Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats

Variable

SHAM

SHAM + TEA

CLP 6 h

CLP 6 h + TEA

CLP 24 h

CLP 24 h + TEA

HR

(beats/min)

396 ± 20

412 ± 24

387 ± 23

412 ± 30

464 ± 16#*

442 ± 37

MAD

(mm Hg)

139 ± 3

130 ± 9

129 ± 8

145 ± 5

133 ± 3

126 ± 6

RR

(rate/minute)

107 ± 8

95 ± 9

94 ± 9

74 ± 6#

130 ± 7#*

115 ± 5

Lactate (mmol/dl)

0.95

(0.9/1.2)

1.1

(1.0/1.53)

1.25

(1.1/1.45)

1.1

(0.93/1.4)

2.3#*

(1.83/3.1)

1.4§

(1.3/1.8)

Leukocytes

(1,000/μl)

5,217 ± 309

7,184 ± 552#

3,868 ± 878

3,194 ± 771#

2,076 ± 343#*

1,752 ± 552#

Hb

(g/dl)

15.6 ± 0.5

14.8 ± 0.2

15.3 ± 0.7

14.3 ± 1.2

14.9 ± 0.2

14.4 ± 1.0

MPO (μU/mg protein)

0.48

(0.42/0.57)

0.47

(0.42/0.81)

0.92

(0.87/1.08)#

0.97

(0.83/1.1)#

2.0

(1.91/2.17)#

0.26

(0.2/1.4)§

W/D

4 ± 1.4

4.4 ± 0.2

5.5 ± 0.2#

5.4 ± 0.3#

5.5 ± 0.2#

5.5 ± 0.1#

  1. Measurements were performed in awake rats. HR = heart rate; MAD = mean arterial pressure; RR = respiratory rate. Data are expressed as mean ± SEM or median, 25%, and 75% percentile. #P < 0.05 versus SHAM; †P < 0.05 versus all CLP groups, §P < 0.05 versus same group without TEA; *P < 0.05 versus hyperdynamic sepsis (CLP 6 h).