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Figure 1 | Critical Care

Figure 1

From: Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats

Figure 1

Illustration of the isolated and perfused lung model. After anesthesia and tracheostomy, exhaled NO (exNO) from rat's lungs was measured, followed by isolation and perfusion of the pulmonary circuit. Angiotensin II (Ang II) was injected into the inflow tract of the circuit to test vasoreactivity. Changes in perfusion pressure (Δp) from baseline were measured in millimeters of mercury. After a stabilization phase, bradykinin (BK)-induced pulmonary vasoconstriction was induced. Therefore, increasing concentrations of BK (1, 3, and 6 μg) were injected into the inflow tract. Changes in perfusion pressure were measured in mm Hg and expressed as Δp from baseline pressure.

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Critical Care

ISSN: 1364-8535