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Figure 6 | Critical Care

Figure 6

From: Unfractionated heparin and enoxaparin reduce high-stretch ventilation augmented lung injury: a prospective, controlled animal experiment

Figure 6

Plasminogen-activator inhibitor-1 (PAI-1)-deficient mice reduced lung stretch–induced mRNA expression and PAI-1 production. Wild-type or PAI-1-/- mice were ventilated at VT 30 ml for 1 hour with room air. (a) RT-PCR assay was performed for PAI-1 mRNA (a, top panel), glyceraldehydes-phosphate dehydrogenase (GAPDH) mRNA (a, middle panel), and arbitrary units (a, bottom panel) (n = 6 per group). Arbitrary units are expressed as the ratio of PAI-1 mRNA to GAPDH. (b) Active PAI-1 production in BAL fluid (n = 6 per group). *P < 0.05 versus control, nonventilated mice; † P < 0.05 versus PAI-1-/- mice.

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Critical Care

ISSN: 1364-8535