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Figure 1 | Critical Care

Figure 1

From: Unfractionated heparin and enoxaparin reduce high-stretch ventilation augmented lung injury: a prospective, controlled animal experiment

Figure 1

Unfractionated heparin and enoxaparin reduced lung stretch-induced microvascular leak, lung edema, and total lung injury. The mice were ventilated at a tidal volume (VT) of 6 ml/kg (VT 6 ml) or 30 ml/kg (VT 30 ml) for 5 hours with room air. Unfractionated heparin, 200 IU/kg or 400 IU/kg, and enoxaparin, 4 mg/kg or 8 mg/kg, was given subcutaneously 30 minutes before ventilation. (a) Evans blue dye (EBD) analysis of lung tissue (n = 6 per group). (b) Lung water measured by lung wet- to dry-weight ratio (n = 6 per group). (c) Total lung-injury scores of hematoxylin and eosin (H&E)-stained paraffin sections (n = 6 per group). * P < 0.05 versus control, nonventilated mice; † P < 0.05 versus all other groups; ‡ P < 0.05 versus 200-IU/kg or 4-mg/kg groups. H = unfractionated heparin; LMWH = enoxaparin.

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