Table 2 Cardiorespiratory changes during study period. Data presented as mean (SD) or median [IQR]

MAP (mm Hg)

71 (± 4)

71 (± 7)

79 (± 9)

75 (± 8)

CVP (mm Hg)

12 (± 4)

12 (± 3)

13 (± 4)

11 (± 3)

PaO₂ (kPa)

14.8

[13.1–18.5]

15.3

[13.6–19.9]

15.2

[11.5–17.8]

13.7

[11.5–14.8]

PaO₂:FiO₂ (kPa)

34 (± 10)

37 (± 7)

36 (± 14)

34 (± 9)

Cumulative fluid balance (ml)

1,903

[1,740–2,631]

2,578

[1,969–2,908]

3,015

[2,294–3,379]

3,457

[2,621–4,506]