Figure 3
From: Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients
Mutant ubiquitin expressing mice are protected from endotoxic shock. Survival of FVB/N transgenic mice expressing wild-type (WT) and mutant ubiquitin (K48R or K63R) after a toxic intraperitoneal dose of 40 mg/kg of lipopolysaccharide. Two independent lines of K63R mice were evaluated (lines 75 and 204). The generation of these lines has been described in previous publications [22, 23].