Figure 1From: Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patientsUbiquitin proteasome pathway. An E1, E2 and E3 complex promotes the ubiquitination of protein substrates via K48 linkage, which predominantly targets substrates for proteasomal degradation. This process is reversible though the action of deubiquitinating enzymes (DUBs) that can cleave ubiquitin from the modified proteins.Back to article page