Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study

Table 2 Association between serum IL-6 and IL-8 levels and acute kidney injury

Cytokine	Odds ratio	95% CI	P value	Odds ratio*	95% CI	P value
IL-6 at 2 hours	3.56	1.28–9.90	0.02	3.47	1.21–9.97	0.02
IL-6 at 12 hours	3.17	1.04–9.66	0.04	3.29	0.86–12.64	0.08
IL-6 at 24 hours	1.45	0.67–3.15	0.34	1.48	0.57–3.80	0.42
IL-8 at 2 hours	2.87	1.25–6.55	0.01	4.98	1.39–17.86	0.01
IL-8 at 12 hours	4.37	1.40–13.64	0.01	9.74	1.75–54.20	0.009
IL-8 at 24 hours	2.44	0.85–6.97	0.10	4.98	0.85–29.15	0.08

Logistic regression was used to determine the association between IL-6 and IL-8 levels at various times after cardiopulmonary bypass and the diagnosis of acute kidney injury. Because biomarker levels were abnormally distributed, they were log transformed, and odds ratios represent the increase in risk per log increase in biomarker level.
*Adjusted for age, sex, race, and previous surgery

ISSN: 1364-8535