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Table 8 PROGRESS DrotAA mortality and clinical outcomes

From: The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes

Variable

DrotAA

n = 882

Non-DrotAA

n = 11,610

Total

n = 12,492

P value

Discharge location by DrotAA use, n (%):

(n = 807)

(n = 10,537)

(n = 11,344)

<0.001

   Died

400 (49.6)

5236 (49.7)

5636 (49.7)

 

   Community

236 (29.2)

3652 (34.7)

3888 (34.3)

 

   Other hospital

73 (9.0)

856 (8.1)

929 (8.2)

 

   Extended/Chronic care Institution

83 (10.3)

620 (5.9)

703 (6.2)

 

   Other/Unknown

15 (1.9)

173 (1.6)

188 (1.7)

 

Hospital mortality for DrotAA therapy, adjusted for Age, 7 OD*, Active Cancer, and Propensity Quartiles†

Adjusted Odds Ratio

95% Confidence Interval

----

P value

All patients**

0.72

0.603 – 0.86

----

0.0003

  1. *Organ Dysfunction (OD).
  2. † See METHODS and Additional data file 1 for details and explanation of this covariate
  3. ** Model #9 used for this analysis.
  4. DrotAA = drotrecogin alfa (activated); PROGRESS = Promoting Global Research Excellence in Severe Sepsis.