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Table 4 PROGRESS disease severity

From: The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes

Variable DrotAA
n = 882
Non-DrotAA
n = 11,610
Total
n = 12,492
P value
Number of organ dysfunctions (OD): (n = 703) (n = 8910) (n = 9613) <0.001
   1 18 (2.6) 1042 (11.7) 1060 (11.0)  
   2 93 (13.2) 1861 (20.9) 1954 (20.3)  
   3 169 (24.0) 2045 (23.0) 2214 (23.0)  
   4 161 (22.9) 1778 (20.0) 1939 (20.2)  
   5 143 (20.3) 1171 (13.1) 1314 (13.7)  
   6 87 (12.4) 677 (7.6) 764 (8.0)  
   7 32 (4.6) 336 (3.8) 368 (3.8)  
Type of dysfunction, n (%):     
   Cardiovascular (n = 882)
791 (89.7)
(n = 11,565)
8536 (73.8)
(n = 12,447)
9327 (74.9)
<0.001
   Respiratory (n = 880)
788 (89.5)
(n = 11,550)
9357 (81.0)
(n = 12,430)
10,145 (81.6)
<0.001
   Hematologic (n = 879)
314 (35.7)
(n = 11,475)
3773 (32.9)
(n = 12,354)
4087 (33.1)
0.08
   Renal (n = 879)
523 (59.5)
(n = 11,480)
5117 (44.6)
(n = 12,359)
5640 (45.6)
<0.001
   Hepatic (n = 771)
150 (19.5)
(n = 10,188)
2111 (20.7)
(n = 10,959)
2261 (20.6)
0.40
   Metabolic (n = 867)
542 (62.5)
(n = 11,266)
4745 (42.1)
(n = 12,133)
5287 (43.6)
<0.001
   Central nervous system (n = 767)
276 (36.0)
(n = 9987)
3686 (36.9)
(n = 10,754)
3962 (36.8)
0.61
APACHE II score, mean (± SD) (n = 610)
25.6 (± 8.5)
(n = 8513)
23.2 (± 8.2)
(n = 9123)
23.4 (± 8.3)
<0.001
Total SOFA score, mean (± SD) (n = 334)
10.3 (± 3.4)
(n = 4785)
9.2 (± 3.9)
(n = 5119)
9.3 (± 3.9)
<0.001
Total MODS score, mean (± SD) (n = 171)
8.6 (± 3.7)
(n = 2244)
6.4 (± 3.6)
(n = 2415)
6.5 (± 3.6)
<0.001
SAPS II score, mean (± SD) (n = 165)
50.2 (± 18.5)
(n = 2831)
49.0 (± 17.3)
(n = 2996)
49.1 (± 17.4)
0.48
  1. APACHE II = Acute Physiology and Chronic Health Evaluation II; DrotAA = drotrecogin alfa (activated); MODS = multiple organ dysfunction syndrome; PROGRESS = Promoting Global Research Excellence in Severe Sepsis; SAPS II = Simplified Acute Physiology Score II; SD = standard deviation; SOFA = Sequential Organ Failure Assessment.