Table 4 PROGRESS disease severity
Variable | DrotAA n = 882 | Non-DrotAA n = 11,610 | Total n = 12,492 | P value |
|---|---|---|---|---|
Number of organ dysfunctions (OD): | (n = 703) | (n = 8910) | (n = 9613) | <0.001 |
   1 | 18 (2.6) | 1042 (11.7) | 1060 (11.0) |  |
   2 | 93 (13.2) | 1861 (20.9) | 1954 (20.3) |  |
   3 | 169 (24.0) | 2045 (23.0) | 2214 (23.0) |  |
   4 | 161 (22.9) | 1778 (20.0) | 1939 (20.2) |  |
   5 | 143 (20.3) | 1171 (13.1) | 1314 (13.7) |  |
   6 | 87 (12.4) | 677 (7.6) | 764 (8.0) |  |
   7 | 32 (4.6) | 336 (3.8) | 368 (3.8) |  |
Type of dysfunction, n (%): | Â | Â | Â | Â |
   Cardiovascular | (n = 882) 791 (89.7) | (n = 11,565) 8536 (73.8) | (n = 12,447) 9327 (74.9) | <0.001 |
   Respiratory | (n = 880) 788 (89.5) | (n = 11,550) 9357 (81.0) | (n = 12,430) 10,145 (81.6) | <0.001 |
   Hematologic | (n = 879) 314 (35.7) | (n = 11,475) 3773 (32.9) | (n = 12,354) 4087 (33.1) | 0.08 |
   Renal | (n = 879) 523 (59.5) | (n = 11,480) 5117 (44.6) | (n = 12,359) 5640 (45.6) | <0.001 |
   Hepatic | (n = 771) 150 (19.5) | (n = 10,188) 2111 (20.7) | (n = 10,959) 2261 (20.6) | 0.40 |
   Metabolic | (n = 867) 542 (62.5) | (n = 11,266) 4745 (42.1) | (n = 12,133) 5287 (43.6) | <0.001 |
   Central nervous system | (n = 767) 276 (36.0) | (n = 9987) 3686 (36.9) | (n = 10,754) 3962 (36.8) | 0.61 |
APACHE II score, mean (± SD) | (n = 610) 25.6 (± 8.5) | (n = 8513) 23.2 (± 8.2) | (n = 9123) 23.4 (± 8.3) | <0.001 |
Total SOFA score, mean (± SD) | (n = 334) 10.3 (± 3.4) | (n = 4785) 9.2 (± 3.9) | (n = 5119) 9.3 (± 3.9) | <0.001 |
Total MODS score, mean (± SD) | (n = 171) 8.6 (± 3.7) | (n = 2244) 6.4 (± 3.6) | (n = 2415) 6.5 (± 3.6) | <0.001 |
SAPS II score, mean (± SD) | (n = 165) 50.2 (± 18.5) | (n = 2831) 49.0 (± 17.3) | (n = 2996) 49.1 (± 17.4) | 0.48 |