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Table 2 PROGRESS clinical characteristics

From: The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes

Variable

DrotAA

n = 882

Non-DrotAA

n = 11,610

Total

n = 12,492

P value

Medical/Surgical Status, n (%):

   

<0.001

   Medical

540 (61.2)

7232 (62.3)

7772 (62.2)

 

   Surgical – Elective

127 (14.4)

1205 (10.4)

1332 (10.7)

 

   Surgical – Emergency

215 (24.4)

3173 (27.3)

3388 (27.1)

 

SIRS criteria met, n (%):

(n = 858)

(n = 11,241)

(n = 12099)

<0.001

   0

2 (0.2)

29 (0.3)

31 (0.3)

 

   1

5 (0.6)

188 (1.7)

193 (1.6)

 

   2

57 (6.6)

1198 (10.7)

1255 (10.4)

 

   3

268 (31.2)

4063 (36.1)

4331 (35.8)

 

   4

526 (61.3)

5763 (51.3)

6289 (52.0)

 

Source of infection, n (%):

(n = 856)

(n = 11,260)

(n = 12,116)

<0.001

   Community acquired

529 (61.8)

6033 (53.6)

6562 (54.2)

 

   Nosocomial – hospital acquired

217 (25.4)

3172 (28.2)

3389 (28.0)

 

   Nosocomial – ICU acquired

110 (12.9)

2055 (18.3)

2165 (17.9)

 

Type of infection, n (%):

(n = 675)

(n = 8380)

(n = 9055)

 

   Gram negative

392 (58.1)

4795 (57.2)

5187 (57.3)

0.67

 

(n = 681)

(n = 8396)

(n = 9077)

 

   Gram positive

371 (54.5)

3668 (43.7)

4039 (44.5)

<0.001

 

(n = 682)

(n = 8678)

(n = 9360)

 

   Fungal

103 (15.1)

986 (11.4)

1089 (11.6)

0.003

Primary site of infection, n (%):

(n = 861)

(n = 11,301)

(n = 12,162)

0.35

   Abdominopelvic

227 (26.4)

2642 (23.4)

2869 (23.6)

 

   Bone or joint

13 (1.5)

160 (1.4)

173 (1.4)

 

   Hematogenous

59 (6.9)

738 (6.5)

797 (6.6)

 

   Indwelling catheter-dialysis access

3 (0.3)

79 (0.7)

82 (0.7)

 

   Indwelling catheter-vascular access

11 (1.3)

163 (1.4)

174 (1.4)

 

   Lung

366 (42.5)

5282 (46.7)

5648 (46.4)

 

   Meninges

12 (1.4)

169 (1.5)

181 (1.5)

 

   Skin or skin structure

44 (5.1)

586 (5.2)

630 (5.2)

 

   Urinary tract

71 (8.2)

887 (7.8)

958 (7.9)

 

   Other

55 (6.4)

595 (5.3)

650 (5.3)

 
  1. DrotAA = drotrecogin alfa (activated); ICU = intensive care unit; PROGRESS = Promoting Global Research Excellence in Severe Sepsis; SIRS = Systemic Inflammatory Response Syndrome.