Results from the national sepsis practice survey: predictions about mortality and morbidity and recommendations for limitation of care orders

Table 8 Factors associated with suggested limitation of care orders, multivariable analyses

	Multivariable analyses
	Adjusted odds ratio (95% CI)	P value	Adjusted odds ratio (95% CI)	P value	Adjusted odds ratio (95% CI)	P value
70 years old (versus 50 years old)	2.90 (1.55 – 5.44)	0.0009	1.90 (0.98 to 3.68)	0.0589	1.87 (0.95 to 3.66)	0.0685
Stage IIA NSCLC (versus no cancer)	7.12 (3.75 – 13.52)	<0.0001	5.70 (2.97 to 10.93)	<0.0001	5.84 (3.05 to 11.20)	<0.0001
BMI 40 kg/m² (versus 22 kg/m²)	1.18 (0.78 – 1.79)	0.4274	1.02 (0.66 to 1.57)	0.9375	1.01 (0.65 to 1.56)	0.9694
Baseline predicted hospital mortality (per 10% increase)			1.30 (1.10 to 1.54)	0.0019	1.29 (1.09 to 1.53)	0.0027
Predicted problems with self-care at six months (per 10% increase)			1.26 (1.12 to 1.41)	<0.0001	1.26 (1.12 to 1.42)	0.0002
Overweight or obese respondent BMI					0.53 (0.29 to 0.96)	0.0345

Limitations of care included suggesting a 'do not resuscitate' order, that there be no further escalation of care (e.g., no addition of vasopressors), and/or termination of supportive care with appropriate 'comfort care' measures. Mortality predictions were estimated prior to any additional chosen care, including limitation of care orders. Respondents were asked to predict the ability to perform self-care (wash and dress oneself) in six months, assuming survival. Multivariable estimates included all variables with displayed estimates in that column. All analyses accounted for non-independence of responses due to respondents completing multiple vignettes.
BMI = body mass index; CI = confidence interval; NSCLC = non-small cell lung carcinoma.

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