Skip to main content

Table 3 Comparison of inflammatory marker levels and cytokeratin measurements in survivors and non-survivors in the septic group at baseline and at 48 and 120 hours

From: Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction

   Survivor (n = 52) Non-survivor (n = 49) P value
IL-6 (pg/ml) t0 104.5; 34.0 to 430.0 249.4; 96.5 to 460.2 0.099
  t48 21.0; 8.0 to 46.0 82.1; 37.4 to 188.5 0.001**
  t120 17.2; 8.9 to 38.3 71.6; 15.7 to 107.1 0.01*
P value t0-t48-t120 < 0.001*** 0.005**  
sICAM-1 (ng/ml) t0 447.5; 323.14 to 663.6 399.8; 327.9 to 655.4 0.841
  t48 434.1; 308.6 to 613.6 683.2; 348.3 to 1003.7 0.067
  t120 467.8; 320.4 to 593.0 630.2; 419.2 to 933.3 0.083
P value t0-t48-t120 0.432 0.829  
sVCAM-1 (ng/ml) t0 1146.3; 911.3 to 1975.7 1227.5; 857.2 to 2242.5 0.837
  t48 882.0; 569.6 to 1236.1 1275.1; 1040.0 to 2799.2 0.027*
  t120 748.5; 639.1 to 1202.6 1685.5; 958.7 to 2201.2 0.021*
P value t0-t48-t120 0.097 0.505  
Total CK-18 (U/l) t0 1581.9; 1030.0 to 2152.0 2006.5; 1169.9 to 4611.6 0.038*
  t48 1579.5; 1359.8 to 2058.7 2007.1; 1239.0 to 4488.8 0.212
  t120 1829.6; 1581.9 to 2076.9 2533.0; 1675.2 to 3535.5 0.073
P value t0-t48-t120 0.396 0.814  
CK-18 fragments (U/l) t0 357.7; 248.8 to 554.8 475.4; 301.5 to 1028.2 0.035*
  t48 355.4; 229.0 to 455.46 603.6; 410.7 to 973.5 0.007**
  t120 324.6; 283.7 to 499.9 508.5; 314.8 to 881.3 0.108
P value t0-t48-t120 0.717 0.939  
Ratio t0 0.3; 0.16 to 0.33 0.2; 0.12 to 0.36 0.436
  t48 0.2; 0.15 to 0.30 0.3; 0.15 to 0.35 0.651
  t120 0.2; 0.15 to 0.27 0.3; 0.15 to 0.36 0.534
P value t0-t48-t120 0.405 0.939  
  1. Data are presented by median and interquartile range (Q1 to Q3).
  2. CK = cytokeratin; sICAM = soluble intercellular adhesion molecule-1; sVCAM = soluble vascular cell adhesion molecule-1.
  3. * P < 0.05; ** P < 0.01; *** P < 0.001.