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Table 2 Comparison of inflammatory marker levels and cytokeratin measurements in the volunteer, postoperative, and septic groups at baseline

From: Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction

  Healthy (n = 18) Postoperative (n = 28) Sepsis (n = 101)
IL-6 (pg/ml) 0.0; 0.0 to 0.8 216.7; 48.8 to 360.5 160.5; 58.8 to 448.8
P values Healthy vs. Postoperative: P < 0.001***
  Healthy vs. Sepsis: P < 0.001***
  Postoperative vs. Sepsis: P = 0.604
sICAM-1 (ng/ml) 219.6; 195.2 to 285.1 213.7; 192.3 to 293.8 444.7; 330.3 to 665.5
P value Healthy vs. Postoperative: P = 0.819
  Healthy vs. Sepsis: P < 0.001***
  Postoperative vs. Sepsis: P < 0.001***
sVCAM-1 (ng/ml) 1524.7; 991.2 to 2038.0 1268.0; 1167.7 to 1550.8 1147.9; 883.5 to 2047.4
P value Healthy vs. Postoperative: P = 0.545
  Healthy vs. Sepsis: P = 0.280
  Postoperative vs. Sepsis: P = 0.450
Total CK-18 (U/l) 241.9; 216.9 to 285.3 558.7; 465.6 to 793.0 1643.8; 1096.5 to 2633.5
P value Healthy vs. Postoperative: P < 0.001***
  Healthy vs. Sepsis: P < 0.001***
  Postoperative vs. Sepsis: P < 0.001***
CK-18 fragments (U/l) 143.7; 134.4 to 168.1 116.0; 106.6 to 165.1 392.6; 258.4 to 654.5
P value Healthy vs. Postoperative: P = 0.250
  Healthy vs. Sepsis: P < 0.001***
  Postoperative vs. Sepsis: P < 0.001***
Ratio 0.58; 0.55 to 0.67 0.22; 0.18 to 0.25 0.24; 0.14 to 0.35
P value Healthy vs. Postoperative: P < 0.001***
  Healthy vs. Sepsis: P < 0.001***
  Postoperative vs. Sepsis: P = 0.507
  1. Data are presented by median and interquartile range (Q1 to Q3).
  2. CK = cytokeratin; sICAM = soluble intercellular adhesion molecule-1; sVCAM = soluble vascular cell adhesion molecule-1.
  3. *** P < 0.001.
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Critical Care

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