Skip to main content

Table 2 Changes in hemodynamic, oxygen transport, and tonometric variables as mean arterial pressure was increased from 65 mmHg to 85 mmHg with norepinephrine

From: Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study

 

Mean arterial blood pressure

ANOVA

Linear trend

 

65 mmHg

75 mmHg

85 mmHg

P

P

Norepinephrine doses (μg/kg/min)

0.48 ± 0.43

0.65 ± 0.68*

0.74 ± 0.67*

< 0.0001

< 0.0001

Heart rate (beats/min)

94 ± 21

92 ± 18

93 ± 18

0.59

0.43

Mean arterial blood pressure (mmHg)

65 ± 2

76 ± 2*

85 ± 2*

< 0.0001

< 0.0001

Mean pulmonary artery pressure (mmHg)

28 ± 7

30 ± 7*

30 ± 7*

< 0.0001

< 0.0001

Pulmonary artery occlusion pressure (mmHg)

14 ± 4

15 ± 4

16 ± 4

0.06

0.02

Central venous pressure (mmHg)

11 ± 4

12 ± 4

12 ± 4

0.18

0.47

Cardiac index (l/min/m 2 )

2.98 ± 0.99

3.11 ± 1.07

3.23 ± 1.02*

0.0002

< 0.0001

Oxygen transport (ml/min/m 2 )

366 ± 137

379 ± 145

383 ± 166

0.53

0.28

Oxygen consumption (ml/min/m 2 )

100 ± 33

91 ± 31

90 ± 40

0.61

0.63

Intramucosal-arterial pCO 2 (mmHg)

15 ± 15

16 ± 18*

16 ± 18

0.03

0.06

  1. * P < 0.05 vs. basal (Dunnett post hoc test after repeated measures ANOVA).
  2. ANOVA = analysis of variance; pCO2 = partial pressure of carbon dioxide.