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Table 2 Changes in hemodynamic, oxygen transport, and tonometric variables as mean arterial pressure was increased from 65 mmHg to 85 mmHg with norepinephrine

From: Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study

  Mean arterial blood pressure ANOVA Linear trend
  65 mmHg 75 mmHg 85 mmHg P P
Norepinephrine doses (μg/kg/min) 0.48 ± 0.43 0.65 ± 0.68* 0.74 ± 0.67* < 0.0001 < 0.0001
Heart rate (beats/min) 94 ± 21 92 ± 18 93 ± 18 0.59 0.43
Mean arterial blood pressure (mmHg) 65 ± 2 76 ± 2* 85 ± 2* < 0.0001 < 0.0001
Mean pulmonary artery pressure (mmHg) 28 ± 7 30 ± 7* 30 ± 7* < 0.0001 < 0.0001
Pulmonary artery occlusion pressure (mmHg) 14 ± 4 15 ± 4 16 ± 4 0.06 0.02
Central venous pressure (mmHg) 11 ± 4 12 ± 4 12 ± 4 0.18 0.47
Cardiac index (l/min/m 2 ) 2.98 ± 0.99 3.11 ± 1.07 3.23 ± 1.02* 0.0002 < 0.0001
Oxygen transport (ml/min/m 2 ) 366 ± 137 379 ± 145 383 ± 166 0.53 0.28
Oxygen consumption (ml/min/m 2 ) 100 ± 33 91 ± 31 90 ± 40 0.61 0.63
Intramucosal-arterial pCO 2 (mmHg) 15 ± 15 16 ± 18* 16 ± 18 0.03 0.06
  1. * P < 0.05 vs. basal (Dunnett post hoc test after repeated measures ANOVA).
  2. ANOVA = analysis of variance; pCO2 = partial pressure of carbon dioxide.