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Table 4 Summary of crude and adjusted ICU and hospital mortality stratified by occurrence of hypoglycemia, and by blood glucose variability, hypoglycemia or neither

From: The impact of early hypoglycemia and blood glucose variability on outcome in critical illness

Blood glucose

Incidence

(%)

ICU mortality

OR (95% CI)

Hospital mortality

OR (95% CI)

  

Crude

Adjusted‡

Crude>

Adjusted§

Early hypoglycemia

     

   Two episodes

1409 (2.1)

3.3 (2.9 to 3.7)

2.4 (2.0 to 2.8)

2.7 (2.4 to 3.0)

2.2 (1.9 to 2.5)

   One episode only

7713 (11.7)

1.9 (1.8 to 2.1)

1.3 (1.2 to 1.4)

1.7 (1.6 to 1.8)

1.2 (1.1 to 1.3)

   No hypoglycemia¶

57062 (86.2)

1.0

1.0

1.0

1.0

BG variability

     

   BG variability

1913 (2.9)

2.7 (2.4 to 3.0)

1.5 (1.4 to 1.6)†

2.4 (2.1 to 2.6)

1.4 (1.3 to 1.5)â–¡

   Hypoglycemia

7209 (10.97)

2.0 (1.8 to 2.1)

1.2 (1.1 to 1.4)†

1.7 (1.6 to 1.8)

1.2 (1.0 to 1.4)â–¡

   Neither¶

57062 (86.2)

1.0

1.0†

1.0

1.0â–¡

  1. APACHE = Acute Physiology and Chronic Health Evaluation; AuROC = area under the receiver operator characteristic curve; BG = blood glucose; CI = confidence interval; ICU = intensive care unit; OR = odds ratio.
  2. ¶Reference variable
  3. ‡ Goodness-of-fit, P = 1.0; AuROC 0.89.
  4. § Goodness-of-fit, P = 1.0; AuROC 0.87.
  5. † Goodness-of-fit, P = 1.0; AuROC 0.89.
  6. â–¡ Goodness-of-fit, P = 1.0; AuROC 0.87.
  7. §‡□† Covariate adjustment for age, sex, surgical status, primary diagnosis, co-morbid illness, non-age-related APACHE II score, mechanical ventilation, acute kidney injury, year, and hospital site.