From: Anemia and red blood cell transfusion in neurocritical care
Study | Patients | Design and setting | Multivariable analysis | Exposure | Outcome | Main result |
---|---|---|---|---|---|---|
Brevig and colleagues [117] | 2531 | Retrospective (prospective database) Single-center | None | Any blood product transfusion | Postoperative CVA (not further defined) | Despite reduction in proportion of patients transfused over time (43% in 2003 vs. 18% in 2007), no change in proportion of patients with CVA (0.8 to 1.5%) |
Ngaage and colleagues [118] | 383 (≥80 years old) | Retrospective (prospective database) Single-center | Logistic regression | Any blood product transfusion | Neurologic complications (confusion/agitation, seizures, TIA, RIND, stroke, or coma) | Transfusion associated with neurologic complications (OR = 3.6 vs. no transfusion, P = 0.003) |
Murphy and colleagues [119] | 8518 | Retrospective Single-center | Logistic regression and propensity scores | Any perioperative RBC transfusion | Composite of MI, stroke (permanent or transient), or renal failure | RBC transfusion was associated with composite outcome (OR = 3.35 for transfusion vs. no transfusion; P < 0.0001) |
Whitson and colleagues [120] | 2691 | Retrospective (prospective database) Single-center | Logistic regression | Any RBC transfusion | CVA (not further defined) | RBC transfusion was associated with CVA (OR = 1.7, P = 0.01) |
Norkiene and colleagues [121] | 1367 | Retrospective Single-center | Logistic regression | Any RBC transfusion | Delirium (DSM-IV criteria) | Postoperative RBC transfusion was associated with delirium (OR = 4.6, P < 0.001) |
Koch and colleagues [122] | 11,963 (CABG) | Retrospective (prospective database) Single-center | Logistic regression | Total number of units of RBCs transfused | Focal or global neurologic deficits or death without awakening | RBC transfusion was associated with stroke (OR = 1.73 for each unit RBCs; P < 0.0001) |
Stamou and colleagues [123] | 49 JW patients | Retrospective Single-center | 196 controls Logistic regression and propensity scores | Any RBC transfusion Nadir Hb not reported | Perioperative stroke | No statistically significant difference in risk of stroke between JWs refusing RBCs and transfused control patients |
Karkouti and colleagues [105] | 10,949 | Retrospective (prospective database) Single-center | Logistic regression | Total number of units of blood product | New perioperative persistent postoperative neurological deficit | Transfusion was associated with stroke (OR = 1.02 for each unit RBCs; P = 0.01) |
Bucerius and colleagues [124] | 16,184 | Retrospective (prospective database) Single-center | Logistic regression | Any perioperative RBC transfusion | Temporary or permanent focal or global neurologic deficit | 'High transfusion requirement' ((≥1000 ml) was associated with stroke (OR = 6.04; P < 0.0001) |
D'Ancona and colleagues [125] | 9916 (CABG) | Retrospective (prospective database) Single-center | Logistic regression | Any blood product transfusion | New temporary or permanent, focal or global neurologic deficit | Transfusion was associated with stroke (OR = 1.59 vs. no transfusion; P = 0.002) |