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Table 4 28-Day mortality and early versus late treatment with DrotAA in patients with clinically stable or worsening status*

From: Early drotrecogin alpha (activated) administration in severe sepsis is associated with lower mortality: a retrospective analysis of the Canadian ENHANCE cohort

Age years

DrotAA <24 hours

DrotAA ≥24 hours

P value

 

n/N

% Mortality

n/N

% Mortality

 

≤49

3/34

8.80

6/44

13.60

0.0409

50 to 64

3/27

11.10

12/43

27.90

 

65 to 74

5/24

20.80

9/25

36.00

 

≥75

6/22

27.27

8/23

34.78

 
  1. P value was based on Cochran-Mantel-Haenszel test adjusted for age (Breslow-Day P > 0.05). * Defined by first day change in serum creatinine or platelet count.
  2. DrotAA = Drotrecogin alfa activated; n = number of patients who died by day 28; N = total number of patients.
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Critical Care

ISSN: 1364-8535