Groups | Lung | Kidney | Liver | Villi |
---|
C-SAL | 0.0 (0 to 1) | 0.0 (0 to 1) | 0.0 (0 to 1) | 0.0 (0 to 1) |
C-Gln | 0.0 (0 to 1) | 0.5 (0 to 1) | 0.5 (0 to 1) | 0.0 (0 to 1) |
CLP-SAL | 2.5 (2 to 4)* | 2.0 (2 to 3)* | 2.0 (2 to 3)* | 3.5 (3 to 4)* |
CLP-Gln | 1.5 (1 to 2)* # | 1.0 (1 to 1)* # | 0.5 (0 to 1) | 0.0 (0 to 1) |
- Values are median (25th to 75th percentile) of five animals in each group. A five-point semiquantitative severity-based scoring system was used. The apoptotic findings were graded as: 0 = normal lung parenchyma; 1 = 1 to 25%; 2 = 26 to 50%; 3 = 51 to 75%; 4 = 76 to 100% of examined tissue. Sepsis was induced by cecal ligation and puncture surgery (CLP). A sham-operated group was used as control group (C) for animals undergoing CLP. One hour after surgery, C and CLP groups were further randomized into subgroups receiving saline (SAL) or glutamine (Gln). *Significantly different from C group (P < 0.05). #Significantly different from CLP-SAL group (P < 0.05).