Table 2 Baseline characteristics of the 1458 patients in the training cohort, on the first day of severe sepsis
From: Model for predicting short-term mortality of severe sepsis
Variables on the day with severe sepsis | Number of episodes of severe sepsis in patients alive 14 days after severe sepsis (n = 1367) | Number of episodes of severe sepsis in patients who died within 14 days after severe sepsis (n = 349) | P value Chi-squared test |
|---|---|---|---|
Organ dysfunctions based on the LOD score | Â | Â | Â |
   Neurological | 386 (28.2) | 155 (44.4) | < 10-4 |
   Cardiovascular | 590 (43.2) | 237 (67.9) | < 10-4 |
   Renal | 1052 (77) | 316 (90.5) | < 10-4 |
   Haematological | 174 (12.7) | 73 (20.9) | < 10-4 |
   Hepatic | 199 (14.6) | 98 (28.1) | < 10-4 |
Procedures | Â | Â | Â |
   Vasoactive and/or inotropic drugs | 681 (49.8) | 249 (71.3) | < 10-4 |
   Mechanical ventilation | 943 (69) | 299 (85.7) | < 10-4 |
   Arterial catheter | 367 (26.8) | 142 (40.7) | < 10-4 |
   Central catheter | 769 (56.3) | 266 (76.2) | < 10-4 |
   Swan catheter | 70 (5.1) | 48 (13.8) | < 10-4 |
   At least one intravascular catheter | 817 (59.8) | 278 (79.7) | < 10-4 |
   Urinary tract catheter | 1081 (79.1) | 311 (89.1) | < 10-4 |
Treatments on the first day of severe sepsis | Â | Â | Â |
   Corticosteroid | 350 (25.6) | 107 (30.7) | 0.06 |
   Antibiotic | 1190 (87.1) | 294 (84.2) | 0.17 |
   Extra-renal replacement therapy | 68 (5) | 51 (14.6) | < 10-4 |
   Early effective antibiotic therapy | 1036 (75.8) | 250 (71.6) | 0.11 |
Microorganism | Â | Â | Â |
   Escherichia coli | 170 (12.4) | 60 (17.2) | 0.02 |
   Streptococcus pneumoniae | 104 (7.6) | 22 (6.3) | 0.41 |
   Pseudomonas species | 153 (11.2) | 52 (14.9) | 0.06 |
   Staphylococcus aureus | 173 (12.7) | 44 (12.6) | 0.98 |
Methicillin-resistant S. aureus | 53 (3.9) | 23 (6.6) | 0.03 |
Methicillin-susceptible S. aureus | 120 (8.8) | 21 (6) | 0.09 |
   Candida species | 42 (3.1) | 20 (5.7) | 0.02 |
   Enterococcus species | 124 (9.1) | 41 (11.7) | 0.13 |
   Acinetobacter baumannii | 14 (1) | 3 (0.9) | 0.78 |
   Other Gram-positive | 110 (8) | 22 (6.3) | 0.27 |
   Multiple organisms | 162 (11.9) | 37 (10.6) | 0.52 |
   Resistant organisms | 95 (6.9) | 33 (9.5) | 0.05 |
   Unknown | 581 (42.5) | 124 (35.5) | 0.02 |
Site of infection | Â | Â | Â |
   Pneumonia | 668 (48.9) | 171 (49) | 0.96 |
   Peritonitis | 187 (13.7) | 55 (15.8) | 0.32 |
   Urinary tract | 186 (13.6) | 52 (14.9) | 0.53 |
   Exacerbation of COPD | 127 (9.3) | 33 (9.5) | 0.92 |
   All forms of bacteraemia | 425 (31.1) | 134 (38.4) | 0.01 |
Primary bacteraemia | 129 (9.4) | 34 (9.7) | 0.86 |
Associated bacteraemia | 296 (21.7) | 100 (28.7) | < 10-2 |
   Catheter-related infection | 86 (6.3) | 22 (6.3) | 0.99 |
   Miscellaneous infection sites | 136 (9.9) | 39 (11.2) | 0.50 |
   Multiple infection sites | 156 (11.4) | 59 (16.9) | < 10-2 |
Rank of severe sepsis episode | Â | Â | 0.01 |
   One | 1177 (86.1) | 281 (80.5) |  |
   Two | 152 (11.1) | 49 (14) |  |
   Three | 30 (2.2) | 17 (4.9) |  |
   Four | 8 (0.6) | 2 (0.6) |  |