Table 1 Baseline characteristics at ICU admission of 1458 patients with severe sepsis
From: Model for predicting short-term mortality of severe sepsis
Variables at ICU admission | Patients alive 14 days after severe sepsis (n = 1177) | Patients who died within 14 days after severe sepsis (n = 281) | P value Chi-squared test |
|---|---|---|---|
Male gender | 725 (61.6) | 188 (66.9) | 0.10 |
Age | 66 (52 to 76) | 69 (56 to 77) | < 10-2 |
Transfer from ward | 600 (51) | 145 (51.6) | 0.85 |
SAPS II | 41 (31 to 53) | 59 (44 to 5) | < 10-4 |
LOD | 4 (2 to 6) | 7 (5 to 10) | < 10-4 |
SOFA | 6 (4 to 8) | 9 (7 to 12) | < 10-4 |
APACHE II | 18 (14 to 22) | 24 (20 to 29) | < 10-4 |
Admission category | (4 missing) | Â | Â |
   Medical | 845 (71.8) | 207 (73.7) | 0.53 |
   Emergency surgery | 230 (19.5) | 52 (18.5) | 0.69 |
   Scheduled surgery | 98 (8.3) | 22 (7.8) | 0.79 |
McCabe score | (4 missing) | (1 missing) | < 10-4 |
   1 | 694 (59) | 99 (35.2) |  |
   2 | 397 (33.7) | 134 (47.7) |  |
   3 | 82 (7) | 47 (16.7) |  |
Main symptom at admission | Â | Â | Â |
   Multiple organ failure | 39 (3.3) | 29 (10.3) | < 10-2 |
   Shock | 367 (31.2) | 105 (37.4) | 0.05 |
   Acute respiratory failure | 384 (32.6) | 73 (26) | 0.03 |
   Exacerbation of COPD | 61 (5.2) | 12 (4.3) | 0.53 |
   Acute renal failure | 50 (4.2) | 10 (3.6) | 0.60 |
   Coma | 140 (11.9) | 39 (13.9) | 0.36 |
   Trauma | 12 (1) | 1 (0.4) | 0.29 |
   Continuous monitoring | 97 (8.2) | 7 (2.5) | < 10-2 |
   Scheduled surgery | 27 (2.3) | 5 (1.8) | 0.60 |
History of immunodeficiency | Â | Â | Â |
   Haematological malignancy | 78 (6.6) | 29 (10.3) | 0.03 |
   Metastatic cancer | 59 (5) | 25 (8.9) | 0.01 |
   AIDS | 41 (3.5) | 16 (5.7) | 0.09 |
   Chemotherapy | 90 (7.6) | 32 (11.4) | 0.04 |
   Steroid therapy | 68 (5.8) | 28 (10) | 0.01 |
   Neutropenia | 42 (3.6) | 13 (4.6) | 0.40 |
Co-morbidities (Knaus definitions) | Â | Â | Â |
   Chronic pulmonary failure | 198 (16.8) | 57 (20.3) | 0.17 |
   Immunodeficiency | 187 (15.9) | 67 (23.8) | < 10-2 |
   Chronic heart failure | 142 (12.1) | 48 (17.1) | 0.02 |
   Chronic hepatic failure | 52 (4.4) | 35 (12.5) | < 10-2 |
   Chronic renal failure | 29 (2.5) | 15 (5.3) | 0.01 |
   Exactly one chronic illness | 405 (34.4) | 136 (48.4) | < 10-4 |
   Two or more chronic illnesses | 94 (8.0) | 42 (15.0) | < 10-3 |
   Diabetes mellitus | 88 (7.5) | 26 (9.3) | 0.32 |
ICU stay (days) | 11 (6 to 23) | 8 (4 to 12) | < 10-4 |
Hospital stay (days) | 33 (19 to 57) | 11 (6 to 17) | < 10-4 |
Type of acquisition of first episode of severe sepsis | Â | Â | 0.46 |
   Community-acquired | 471 (40) | 102 (36.3) |  |
   Hospital-acquired | 454 (38.7) | 112 (39.9) |  |
   ICU-acquired | 252 (21.4) | 67 (23.8) |  |