Cytomegalovirus infection in critically ill patients: a systematic review

Table 2 Characteristics of studies assessing the rate of cytomegalovirus pneumonia in critically ill patients

				CMV infection			Outcome CMV positive vs. negative
Study	Inclusion criteria	Number of patients	CMV IgG^a	Time of histologic examination, day	Methods	Rate^a	Mortality, death/total (%)	ICU stay
[31]	ICU, acute respiratory failure or VAP, negative BAL cultures	86	13/18 (72)	18 (10–40)^b	Autopsy or open-lung biopsy	25/86 (29)	ND	No difference
[30]	ICU, ≥ 5 days of evolution of ARDS, negative microbiological cultures	36	ND	10 (5–55)^c	Open-lung biopsy	18/36 (50)	ND	ND
[29]	ICU, ≥ 5 days of evolution of ARDS, negative microbiological cultures	100^d	ND	7 (6–13.5)^c	Open-lung biopsy	30/100 (30)	ND	ND
					Lung tissue culture	10/100 (10)

ARDS = acute respiratory distress syndrome; BAL = bronchoalveolar lavage; CMV = cytomegalovirus; ICU = intensive care unit; NA = not applicable; ND = no data available; VAP = ventilator-associated pneumonia.
^a Data were presented as positive/total (%).
^b Time was measured after the ICU admission.
^c Time was measured after the onset of ARDS.
^d Four immunocompromised patients were included.

ISSN: 1364-8535