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Table 2 Characteristics of studies assessing the rate of cytomegalovirus pneumonia in critically ill patients

From: Cytomegalovirus infection in critically ill patients: a systematic review

     CMV infection Outcome CMV positive vs. negative
Study Inclusion criteria Number of patients CMV IgGa Time of histologic examination, day Methods Ratea Mortality, death/total (%) ICU stay
[31] ICU, acute respiratory failure or VAP, negative BAL cultures 86 13/18 (72) 18 (10–40)b Autopsy or open-lung biopsy 25/86 (29) ND No difference
[30] ICU, ≥ 5 days of evolution of ARDS, negative microbiological cultures 36 ND 10 (5–55)c Open-lung biopsy 18/36 (50) ND ND
[29] ICU, ≥ 5 days of evolution of ARDS, negative microbiological cultures 100d ND 7 (6–13.5)c Open-lung biopsy 30/100 (30) ND ND
      Lung tissue culture 10/100 (10)   
  1. ARDS = acute respiratory distress syndrome; BAL = bronchoalveolar lavage; CMV = cytomegalovirus; ICU = intensive care unit; NA = not applicable; ND = no data available; VAP = ventilator-associated pneumonia.
  2. a Data were presented as positive/total (%).
  3. b Time was measured after the ICU admission.
  4. c Time was measured after the onset of ARDS.
  5. d Four immunocompromised patients were included.