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Table 2 Time course after LPS challenge in healthy subjects

From: Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis

Time course after LPS challenge
Variables Pre-dose 1 hour 1.5 hours 2 hours 2.5 hours 3.5 hours 4.5 hours 6.5 hours 8 hours 24 hours P value
Systolic BP (mmHg) 140 ± 14 139 ± 11 152 ± 11 158 ± 18 151 ± 18 142 ± 22 121 ± 18 107 ± 11 104 ± 11 131 ± 11 < 0.0001
Diastolic BP (mmHg) 74 ± 10 74 ± 7 80 ± 7 77 ± 12 65 ± 12 61 ± 14 54 ± 11 55 ± 8 55 ± 7 66 ± 7 < 0.0001
MAP (mmHg) 96 ± 11 96 ± 9 104 ± 7 104 ± 13 94 ± 14 88 ± 16 77 ± 13 72 ± 8 71 ± 7 88 ± 7 < 0.0001
Heart rate (beats/minute) 61 ± 16 59 ± 11 78 ± 19 78 ± 18 92 ± 12 98 ± 8 101 ± 8 97 ± 11 96 ± 13 81 ± 16 < 0.0001
HR/MAP index 0.64 ± 0.11 0.62 ± 0.11 0.75 ± 0.17 0.76 ± 0.22 1.01 ± 0.22 1.15 ± 0.26 1.36 ± 0.32 1.36 ± 0.27 1.4 ± 0.22 0.92 ± 0.16 < 0.0001
Body temperature (°C) 35.4 ± 0.38 36.2 ± 0.54 36.4 ± 0.87 37.0 ± 1.04 37.6 ± 1.11 38.5 ± 0.66 38.9 ± 0.53 38.14 ± 0.28 37.9 ± 0.19 36.2 ± 0.29 < 0.0001
White blood count (103/μl) 5.5 ± 0.7 - - - - - - - - 10.9 ± 1.6 0.03
C-reactive protein (mg/l) 1.1 ± 2.4 0.9 ± 1.8 - - 1.5 ± 2.4 2.2 ± 2.5 1.1 ± 2.3 1.8 ± 2.8 4.8 ± 2.0 60.0 ± 21.5 < 0.0001
Ang-1 (ng/ml) 67.0 ± 20.7 58.2 ± 24.4 - - 61.2 ± 25.0 54.3 ± 19.5 - 64.9 ± 29.1 60.3 ± 31.4 52.3 ± 21.6 0.053
Ang-2 (ng/ml) 0.57 ± 0.50 0.63 ± 0.20 1.04 ± 0.65 1.63 ± 0.89 2.33 ± 0.69 2.35 ± 1.06 2.42 ± 1.32 2.23 ± 1.18 1.61 ± 1.07 1.51 ± 1.03 < 0.0001
Tie2 (ng/ml) 1.34 ± 0.31 1.23 ± 0.29 1.33 ± 0.32 1.53 ± 0.52 1.23 ± 0.20 1.3 ± 0.16 1.31 ± 0.35 1.4 ± 0.3 1.25 ± 0.32 1.43 ± 0.42 0.085
  1. A non-parametric repeated-measures analysis of variance (Friedman's test) was used to test for significant changes of variables during the time course after LPS challenge (placebo group; n = 6). ANG = angiopoietin; BP = blood pressure; HR = heart rate; LPS = lipopolysaccharide; MAP = mean arterial pressure.