Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis

Table 2 Time course after LPS challenge in healthy subjects

Time course after LPS challenge
Variables	Pre-dose	1 hour	1.5 hours	2 hours	2.5 hours	3.5 hours	4.5 hours	6.5 hours	8 hours	24 hours	P value
Systolic BP (mmHg)	140 ± 14	139 ± 11	152 ± 11	158 ± 18	151 ± 18	142 ± 22	121 ± 18	107 ± 11	104 ± 11	131 ± 11	< 0.0001
Diastolic BP (mmHg)	74 ± 10	74 ± 7	80 ± 7	77 ± 12	65 ± 12	61 ± 14	54 ± 11	55 ± 8	55 ± 7	66 ± 7	< 0.0001
MAP (mmHg)	96 ± 11	96 ± 9	104 ± 7	104 ± 13	94 ± 14	88 ± 16	77 ± 13	72 ± 8	71 ± 7	88 ± 7	< 0.0001
Heart rate (beats/minute)	61 ± 16	59 ± 11	78 ± 19	78 ± 18	92 ± 12	98 ± 8	101 ± 8	97 ± 11	96 ± 13	81 ± 16	< 0.0001
HR/MAP index	0.64 ± 0.11	0.62 ± 0.11	0.75 ± 0.17	0.76 ± 0.22	1.01 ± 0.22	1.15 ± 0.26	1.36 ± 0.32	1.36 ± 0.27	1.4 ± 0.22	0.92 ± 0.16	< 0.0001
Body temperature (°C)	35.4 ± 0.38	36.2 ± 0.54	36.4 ± 0.87	37.0 ± 1.04	37.6 ± 1.11	38.5 ± 0.66	38.9 ± 0.53	38.14 ± 0.28	37.9 ± 0.19	36.2 ± 0.29	< 0.0001
White blood count (10³/μl)	5.5 ± 0.7	-	-	-	-	-	-	-	-	10.9 ± 1.6	0.03
C-reactive protein (mg/l)	1.1 ± 2.4	0.9 ± 1.8	-	-	1.5 ± 2.4	2.2 ± 2.5	1.1 ± 2.3	1.8 ± 2.8	4.8 ± 2.0	60.0 ± 21.5	< 0.0001
Ang-1 (ng/ml)	67.0 ± 20.7	58.2 ± 24.4	-	-	61.2 ± 25.0	54.3 ± 19.5	-	64.9 ± 29.1	60.3 ± 31.4	52.3 ± 21.6	0.053
Ang-2 (ng/ml)	0.57 ± 0.50	0.63 ± 0.20	1.04 ± 0.65	1.63 ± 0.89	2.33 ± 0.69	2.35 ± 1.06	2.42 ± 1.32	2.23 ± 1.18	1.61 ± 1.07	1.51 ± 1.03	< 0.0001
Tie2 (ng/ml)	1.34 ± 0.31	1.23 ± 0.29	1.33 ± 0.32	1.53 ± 0.52	1.23 ± 0.20	1.3 ± 0.16	1.31 ± 0.35	1.4 ± 0.3	1.25 ± 0.32	1.43 ± 0.42	0.085

A non-parametric repeated-measures analysis of variance (Friedman's test) was used to test for significant changes of variables during the time course after LPS challenge (placebo group; n = 6). ANG = angiopoietin; BP = blood pressure; HR = heart rate; LPS = lipopolysaccharide; MAP = mean arterial pressure.

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