From: Remifentanil discontinuation and subsequent intensive care unit-acquired infection: a cohort study
Characteristic | ICU-acquired infection n = 233 | No ICU-acquired infection n = 354 | P value | OR (95% CI) |
---|---|---|---|---|
Central venous catheter | 224 (96) | 246 (69) | < 0.001 | 10.9 (5.40 to 22.08) |
Duration of central venous catheter use, days | 25 ± 19 | 13 ± 9 | < 0.001 | |
Arterial catheter | 218 (93) | 218 (61) | < 0.001 | 9.06 (5.15 to 15.9) |
Duration of arterial catheter use, days | 25 ± 19 | 12 ± 7 | < 0.001 | |
Urinary catheter | 223 (95) | 281 (79) | < 0.001 | 5.79 (2.92 to 11.47) |
Duration of urinary catheter use, days | 25 ± 19 | 13 ± 9 | < 0.001 | |
Mechanical ventilation | 225 (96) | 244 (68) | < 0.001 | 12.6 (6.04 to 26.5) |
Duration of mechanical ventilation, days | 24 ± 18 | 11 ± 7 | < 0.001 | |
Reintubation | 33 (14) | 18 (5) | < 0.001 | 3.08 (1.69 to 5.61) |
Tracheostomy | 55 (23) | 24 (6) | < 0.001 | 4.24 (2.54 to 7.09) |
Fibreoptic bronchoscopy | 140 (60) | 93 (26) | < 0.001 | 4.22 (2.96 to 6.01) |
Digestive tract endoscopy | 52 (22) | 32 (9) | < 0.001 | 2.89 (1.79 to 4.65) |
Antimicrobial treatment | 211 (90) | 286 (80) | 0.001 | 2.28 (1.36 to 3.80) |
Duration of antimicrobial treatment, days | 19 ± 16 | 11 ± 6 | < 0.001 | |
Remifentanil use | 203 (87) | 191 (53) | < 0.001 | 5.77 (3.73 to 8.93) |
Duration of remifentanil use, days | 12 ± 11 | 7 ± 4 | < 0.001 | |
Dose of remifentanil, mg/kg/day | 0.73 ± 0.25 | 0.61 ± 0.21 | 0.083 | |
Remifentanil discontinuation | 153 (65) | 133 (37) | < 0.001 | 3.17 (2.24 to 4.49) |
Midazolam use | 136 (58) | 106 (29) | < 0.001 | 3.28 (2.32 to 4.63) |
Duration of midazolam use, days | 9 ± 7 | 5 ± 4 | < 0.001 | |
Dose of midazolam, mg/kg/days | 1.76 ± 0.91 | 1.36 ± 0.70 | 0.183 | |
Midazolam discontinuation | 86 (36) | 73 (20) | < 0.001 | 2.25 (1.55 to 3.26) |
Ramsay score | 3.6 ± 1 | 2.7 ± 1 | 0.043 | |
Neuromuscular blocking agent use | 36 (15) | 25 (7) | 0.001 | 2.40 (1.40 to 4.12) |
Acute withdrawal | 48 (20) | 32 (9) | < 0.001 | 2.61 (1.61 to 4.23) |
Length of stay before ICU-acquired infection, days | 24 ± 19 | 11 ± 8 | < 0.001 |