Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury

Table 5 Sensitivity analysis for ICU mortality in CRRT patients

CRRT dose expressed as	Unadjusted OR with 95% CI	Pvalue	Adjusted OR with 95% CI	Pvalue
Raw value (ml/kg/hour)	1.00 (0.98 to 1.02)	0.827	0.99 (0.97 to 1.02)	0.583
Increment of 10 ml/kg/hour	1.05 (0.87 to 1.26)	0.638	0.98 (0.79 to 1.23)	0.879
Literature cut-offs
≤ 20 ml/kg/hour (ref.)	1.00		1.00
21 to 34 ml/kg/hour	1.09 (0.61 to 1.93)	0.768	0.79 (0.40 to 1.55)	0.492
≥ 35 ml/kg/hour	1.50 (0.76 to 2.98)	0.245	1.00 (0.45 to 2.24)	0.995
Less-intensive (< 35 ml/kg/hour) (ref.)	1.00		1.00
More-intensive (≥ 35 ml/kg/hour)	1.41 (0.83 to 2.38)	0.204	1.21 (0.66 to 2.21)	0.537
≤ 20 ml/kg/hour (ref.)
> 20 ml/kg/hour	1.19 (0.68 to 2.07)	0.546	0.84 (0.43 to 1.61)	0.595
Tertiles
1st tertile (≤ 23.5 ml/kg/hour) (ref.)	1.00		1.00
2nd tertile (23.6 to 30.9 ml/kg/hour)	0.71 (0.42 to 1.20)	0.206	0.67 (0.37 to 1.23)	0.196
3rd tertile (≥ 31 ml/kg/hour)	1.32 (0.78 to 2.24)	0.306	1.11 (0.60 to 2.06)	0.734
1st+2nd tertiles (ref.)
3rd tertile	1.56 (0.98 to 2.48)	0.058	1.36 (0.79 to 2.32)	0.268
Median
< Median (ref.)	1.00		1.00
≥ Median (≥ 27.1 ml/kg/hour)	0.99 (0.64 to 1.51)	0.945	0.82 (0.49 to 1.35)	0.433
CRRT dose in first 24 hours
Less-intensive (< 35 ml/kg/hour) (ref.)	1.00		1.00
More-intensive (≥ 35 ml/kg/hour)	1.02 (0.65 to 1.62)	0.918	0.96 (0.57 to 1.60)	0.866
CRRT dose in first 48 hours
Less-intensive (< 35 ml/kg/hour) (ref.)	1.00		1.00
More-intensive (≥ 35 ml/kg/hour)	1.08 (0.68 to 1.74)	0.737	1.03 (0.60 to 1.76)	0.915

CI = confidence interval; CRRT = continuous renal replacement therapy; ICU = intensive care unit; OR = odds ratio.

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