Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury

Table 3 Clinical characteristics of IRRT patients by IRRT dose (< 6 and ≥ 6 sessions per week)

	Frequency < 6 days/week	Frequency ≥ 6 days/week	P
n (%)	31 (36)	56 (64)
Male sex (%)	71.0	69.6	0.897
Age (years)	69.13 ± 11.7	67.84 ± 13.7	0.873
Body weight (kg)	79.52 ± 15.7	76.99 ± 21.6	0.246
ICU admission
SAPS II	49 ± 15	50 ± 20	0.958
SOFA	10 ± 3	9 ± 4	0.689
Creatinine (μmol/L)	106 (80 to 186)	106 (80 to 177)	0.822
Chronic kidney disease (%)	54.8	55.4	0.963
Diagnosis
Sepsis (%)	3.2	21.4	0.023
Post-surgical (%)	64.5	44.6	0.076
Admission department
Emergency (%)	12.9	23.2	0.245
Medicine (%)	12.9	12.5	0.957
Surgery (%)	74.2	64.3	0.343
Hospital to ICU admission (days)	3 (0 to 8)	1 (0 to 6)	0.322
RRT
ICU admission to RRT (days)	5 (1 to 11)	3 (1 to 7)	0.351
RIFLE class at RRT initiation
Risk (%)	6.5	5.4	0.834
Injury (%)	41.9	25.0	0.102
Failure (%)	51.6	66.1	0.186
Non renal indication (%)	0.0	3.6	0.287
SOFA at RRT initiation	10 ± 2	10 ± 2	0.941
Creatinine at RRT initiation (μmol/L)	247 (199 to 296)	234 (212 to 301)	0.880
Number of sessions per week	4.5 ± 0.8	6.9 ± 0.2	< 0.001
Start to end RRT (days)	6 (5 to 12)	3 (1 to 5)	< 0.001
Indication for RRT initiation
Azotaemia	96.8	80.4	0.033
RIFLE class	58.1	62.5	0.685
Fluid overload	41.9	57.1	0.174
Oliguria	22.6	32.1	0.345
Outcome
ICU mortality (%)	19.4	23.6	0.646
Mechanical ventilation (days)	14 (5 to 21)	6 (0 to 14)	0.030
ICU length of stay (days)	18 (13 to 31)	9.5 (6 to 18)	0.023

ICU = intensive care unit; IRRT = intermittent renal replacement therapy; RIFLE = Risk-Injury-Failure-Loss-Endstage renal disease; RRT = renal replacement therapy; SAPS II = simplified acute physiology score; SOFA = sequential organ failure assessment.

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