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Table 2 Clinical characteristics of CRRT patients by CRRT dose (≤ 20, 21 to 34, and ≥ 35 ml/kg/hour)

From: Delivered dose of renal replacement therapy and mortality in critically ill patients with acute kidney injury

 

Less-intensive (< 35 ml/kg/hour)

More-intensive

 
 

≤ 20 ml/kg/hour

21 to 34 ml/kg/hour

≥ 35 ml/kg/hour

P

n (%)

61 (18)

202 (60)

75 (22)

 

Male sex (%)

73.8

67.8

58.1

0.139

Age (years)

59.05 ± 19.0

63.48 ± 15.9

61.01 ± 17.4

0.226

Body weight (kg)

91.66 ± 24.4

79.70 ± 18.0

68.81 ± 12.8

< 0.001

ICU admission

    

   SAPS II

46 ± 19

51 ± 17

52 ± 16

0.030

   SOFA

9 ± 4

10 ± 3

11 ± 4

0.030

   Creatinine (μmol/L)

106 (88 to 150)

97 (80 to 150)

106 (80 to 150)

0.597

   Chronic kidney disease (%)

47.5

58.9

55.4

0.290

Diagnosis

    

   Sepsis (%)

31.2

40.1

40.5

0.419

   Post-surgical (%)

24.6

21.3

21.6

0.859

Admission department

    

   Emergency (%)

36.1

35.2

25.7

0.292

   Medicine (%)

16.4

23.3

32.4

0.087

   Surgery (%)

47.5

41.6

41.9

0.702

   Hospital to ICU admission (days)

0.5 (0 to 4)

1 (0 to 4)

1 (0 to 3)

0.654

RRT

    

   ICU admission to RRT (days)

2.5 (2 to 8)

3 (2 to 7)

2 (1 to 3)

0.005

   RIFLE class at RRT initiation

    

Risk (%)

19.7

9.9

13.5

0.123

Injury (%)

18.0

27.7

35.1

0.086

Failure (%)

55.7

59.9

50.0

0.331

Non-renal indication (%)

6.6

2.5

1.4

0.168

   SOFA at RRT initiation

11 ± 3

12 ± 3

12 ± 3

0.068

   Creatinine at RRT initiation (μmol/L)

283 (177 to 389)

283 (194 to 415)

221 (168 to 327)

0.052

   CRRT dose (ml/kg/hour)

15.4 ± 4.2

26.9 ± 4.0

44.8 ± 9.4

< 0.001

   Start to end RRT (days)

3 (2 to 6)

4 (2 to 8)

2 (1 to 3)

< 0.001

Indication for RRT initiation

    

   Azotaemia

65.0

70.0

63.9

0.559

   RIFLE class

56.7

70.0

56.9

0.048

   Fluid overload

61.7

62.5

59.7

0.917

   Oliguria

49.5

41.7

48.6

0.562

Outcome

    

   ICU mortality (%)

50.8

53.0

60.8

0.426

   Mechanical ventilation (days)

13 (3 to 23)

12 (5 to 20)

5 (2.5 to 13)

< 0.001

   ICU length of stay (days)

17 (7.5 to 29)

15 (9 to 27)

8 (4 to 18)

< 0.001

  1. CRRT = continuous renal replacement therapy; ICU = intensive care unit; RIFLE = Risk-Injury-Failure-Loss-Endstage renal disease; RRT = renal replacement therapy; SAPS II = simplified acute physiology score; SOFA = sequential organ failure assessment.