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Figure 1 | Critical Care

Figure 1

From: Prolonged treatment with N-acetylcystine delays liver recovery from acetaminophen hepatotoxicity

Figure 1

Effect of treatment with NAC or saline on serum ALT/AST in an APAP-induced ALI model. (a, b) Acute liver injury (ALI) was induced in C57Bl/6 male mice with a single dose of acetaminophen (APAP) (350 mg/kg) by intraperitoneal injection. Two hours after APAP injection, the animals were treated with 100 mg/kg N-acetyl-cysteine (NAC) dissolved in 0.6 mL saline or 0.6 mL saline every 12 hours. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured 24 hours after APAP injection (n = 6 surviving mice for each group). Results are means ± standard error of the mean (SEM). * P < 0.05 versus control; † P < 0.05 vs. the NAC group. (c, d) Three separate groups of mice were used. ALI was induced as described above. Two hours after APAP challenge, the animals were given the same treatment every 12 hours for a total of 72 hours. ALT and AST were measured 72 hours after APAP injection (n = 6 to 7 surviving mice for each group). Results are means ± SEM. * P < 0.05 vs. control; † P < 0.05 vs. the NAC group.

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