Inhaled aerosolised recombinant human activated protein C ameliorates endotoxin-induced lung injury in anaesthetised sheep

Table 1 Effects of inhaled activated protein C on lipopolysaccharide-induced changes in oxygen related variables and body temperature.

	0 hour	2 hours	4 hours	6 hours
SaO₂, %
Sham	97 ± 1	98 ± 0	98 ± 1	98 ± 1
LPS	97 ± 1	86 ± 3^a	84 ± 3^a	84 ± 4^a
LPS+inhAPC	98 ± 1	86 ± 3^a	93 ± 2^ab	94 ± 1^ab
SvO₂, %
Sham	68 ± 2	69 ± 2	68 ± 2	67 ± 2
LPS	64 ± 2	58 ± 4	51 ± 4^a	54 ± 5^a
LPS+inhAPC	68 ± 2	58 ± 3^a	65 ± 3^bc	64 ± 4^b
Temp, C°
Sham	38.1 ± 0.3	38.4 ± 0.4	38.8 ± 0.4^ab	38.8 ± 0.4^ab
LPS	38.3 ± 0.3	39.4 ± 0.3^a	40.2 ± 0.2^ab	40.4 ± 0.3^ab
LPS+inhAPC	38.3 ± 0.1	39.4 ± 0.1^a	40.3 ± 0.1^ab	40.5 ± 0.1^ab
Hb, g/dL
Sham	8 ± 0	9 ± 0	9 ± 0	8 ± 0
LPS	9 ± 1	11 ± 1^a	11 ± 1^a	11 ± 1^a
LPS+inhAPC	9 ± 0	12 ± 0^a	12 ± 0^a	11 ± 0^a
pH
Sham	7.53 ± 0.01	7.54 ± 0.01	7.56 ± 0.01	7.53 ± 0.01
LPS	7.52 ± 0.01	7.51 ± 0.02	7.51 ± 0.02	7.52 ± 0.02
LPS+inhAPC	7.51 ± 0.01	7.48 ± 0.02	7.53 ± 0.02^bc	7.54 ± 0.01^ab
PaCO₂
Sham	37 ± 2	36 ± 2	35 ± 1	34 ± 2
LPS	40 ± 2	41 ± 2	41 ± 2	39 ± 2
LPS+APC	40 ± 1	42 ± 3	37 ± 2^b	37 ± 1^b

Data presented as the mean ± standard error of the mean.
Hb = haemoglobin; LPS = sheep receiving infusion of lipopolysaccharide (n = 8); LPS+inhAPC = sheep receiving LPS and inhaled nebulised recombinant human activated protein C (n = 8); PaCO₂ = arterial carbon dioxide partial pressure; pH = arterial pH;. SaO₂ = arterial oxygen saturation; Sham = sham operated sheep (n = 8); SvO₂ = central venous oxygen saturation; Temp = body temperature.
^aP < 0.05 from t = 0 hours; ^bP < 0.05 from t = 2 hours; ^cP < 0.05 between LPS and LPS+inhAPC-groups.

ISSN: 1364-8535