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Table 2 Stability of time-dependent antibiotics in solution for intravenous infusion

From: Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock – does the dose matter?

Antibiotic Time of stability at room temperature (+25°C; hours) Maximum concentration tested (mg/l) Solvent
Piperacillin/tazobatam [52] >72 128,000 Sterile water for injection
Ceftazidime [52] 24 120,000 Sterile water for injection
Cefepime [52] 13 50,000 Sterile water for injection
Imipenem [52] 3.30 8,000 Sterile water for injection
Meropenem [52] 5.15 64,000 Sterile water for injection
Vancomycin [53] >696 NA Sterile water for injection, sodium chloride solution (0.9%; pH 5.4), dextrose solution (5%; pH 4.2)
  1. Stability was defined as times during which antibiotic remains >90% stable in solution. NA, not applicable.