Figure 4From: Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock – does the dose matter?Pharmacodynamics of a time-dependent antimicrobial. Shown is a comparison of the simulated drug concentration profile of a time-dependent anitmicrobial with an elimination half-life of 1 hour administered over 30 minutes or over 3 hours. The extended infusion time increases the time for which the antibiotic concentration exceeds the minimum inhibitory concentration (t>MIC). Dotted line refers to a MIC of 8 mg/l.Back to article page