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Figure 4 | Critical Care

Figure 4

From: Bench-to-bedside review: Appropriate antibiotic therapy in severe sepsis and septic shock – does the dose matter?

Figure 4

Pharmacodynamics of a time-dependent antimicrobial. Shown is a comparison of the simulated drug concentration profile of a time-dependent anitmicrobial with an elimination half-life of 1 hour administered over 30 minutes or over 3 hours. The extended infusion time increases the time for which the antibiotic concentration exceeds the minimum inhibitory concentration (t>MIC). Dotted line refers to a MIC of 8 mg/l.

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