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Table 1 Characteristics of the seven adult studies included in the meta-analysis

From: Effects of steroids on reintubation and post-extubation stridor in adults: meta-analysis of randomised controlled trials

Author, year Jadad
scale
Overall
sample
size analysed
(n)
ICU population
and inclusion criteria
Duration of ventilation
(days)
(steroid vs placebo)
Steroid dose and
regimen administration
Overall
equivalent dose of
hydrocortisone (mg)
Cheng and colleagues 2007[8] 3 71 Medical and surgical
MV for more than 24 hours
High risk of stridor (CLV < 24%)
NR Methylprednisolone IV 40 mg, 4 hours before extubation 200
Cheng and colleagues 2006[9] 5 128 Medical and surgical
MV for more than 24 hours
High risk of stridor (CLV < 24%)
7.3 ± 3.9 (1 inj)
6.3 ± 3.8 (4 inj)
vs 7.1 ± 4.1 (placebo)
Methylprednisolone IV 40 mg/6 hours × 4 vs Methylprednisolone IV 40 mg – 1 injection vs placebo
Started 24 hours before extubation
800 or 200
Darmon and colleagues 1992[10] 5 694 Medical and surgical
MV for more than 36 hours
Not selected at high-risk
9.6 ± 9.7
vs 10.3 ± 10.9
Dexamethasone IV 8 mg one hour before extubation 213
Francois and colleagues 2007[11] 5 698 Medical, surgical and trauma
MV for more than 36 hours
Not selected at high-risk
Duration of MV < 7 days: 51 vs 49%
Duration of MV > 7 days: 49 vs 51%
Methylprednisolone IV 20 mg/4 hours starting 12 hours before planned extubation (last dose just before extubation) 400
Ho and colleagues 1996[12] 5 77 Medical and surgical
Not selected at high-risk
6.1 ± 3.8
vs 4.6 ± 4.7
Hydrocortisone IV 100 mg one hour before extubation 100
Lee and colleagues 2007[13] 5 86 Medical
MV for more than 48 hours
High risk of stridor (CLV < 110 ml)
7.0 ± 2.0
vs 6.6 ± 2.0
Dexamethasone IV 5 mg/6 hours × 4 – started 24 hours before extubation, last dose just before extubation 533
Shih and colleagues 2007[14] 3 98 Medical and surgical
MV for more than 24 hours
Between 10 and 15 Hydrocortisone IV 4 injections/6 hours
Started 24 hours before
NR
  1. CLV = cuff-leak volume; ICU = intensive care unit; IV = intra-venous; MV = mechanical ventilation; NR = not reported.