From: Impact of intraoperative lung-protective interventions in patients undergoing lung cancer surgery
 | Historical control cohort (n = 533) | PLV cohort (n = 558) | P value |
---|---|---|---|
Preoperative chemotherapy | 10.8 | 14.4 | 0.080 |
Type of surgery (% cases) | Â | Â | Â |
   Pneumonectomy or bi-lobectomy | 21.4 | 17.6 | 0.129 |
   Lobectomy | 54.2 | 56.1 | 0.575 |
   Lesser resection | 18.7 | 20.5 | 0.542 |
   Explorative thoracotomy | 5.4 | 3.2 | 0.099 |
Pathologic stage (% patients) | Â | Â | Â |
   Ia and Ib | 42 | 44 | 0.531 |
   IIa and IIb | 22 | 23 | 0.750 |
   IIIa | 18 | 19 | 0.733 |
   IIIb and IV | 11 | 8 | 0.389 |
   Other | 7 | 6 | 0.833 |
Thoracic epidural analgesia (% patients) | 83.7 | 95.0* | < 0.001 |
Intraoperative period | Â | Â | Â |
   Duration of anesthesia (minutes) | 166 (62) | 176 (74) | 0.228 |
   Duration of surgery (minutes) | 114 (47) | 121 (56) | 0.354 |
   Duration of one-lung ventilation (minutes) | 71 (18) | 74 (20) | 0.421 |
   Total intraoperative fluid intake (ml/kg/hour) | 5.6 (2.8) | 5.8 (2.9) | 0.587 |
   Intravenous crystalloids (ml/kg/hour) | 3.6 (1.4) | 3.5 (1.6) | 0.652 |
   Intravenous colloids (ml/kg/hour) | 2.0 (1.5) | 2.3 (1.8) | 0.187 |
   Red blood cell transfusion (% patients) | 1.50 | 1.61 | 0.991 |
   Urine output (ml/kg/hour) | 1.8 (1.2) | 1.5 (1.4) | 0.287 |
   Phenylephrine (mg) | 528 (443) | 588 (487) | 0.338 |
   Ephedrine (mg) | 15 (13) | 16 (14) | 0.542 |
   Cumulative fluid intake (24 hours) (ml/kg/hour) | 6.4 (3.2) | 6.6 (3.1) | 0.385 |
Postoperative period | Â | Â | Â |
   Total fluid intake (ml/24 hours) | 1,657 (573) | 1,496 (608) | 0.182 |
   Red blood cell transfusion (% patients) | 2.25 | 1.79 | 0.890 |
   Urine output (ml/24 hours) | 868 (334) | 781 (234) | 0.254 |
   Chest drainage (ml/24 hours) | 378 (172) | 342 (125) | 0.774 |
   PaO2/FIO2 (kPa) | 45.1 (6.2) | 44.7 (5.9) | 0.513 |
   Blood hemoglobin at POD1 (g/l) | 119 (13) | 121 (20) | 0.834 |
   Serum creatinine at POD1 (mg/l) | 93 (30) | 84 (31) | 0.303 |